(1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Base Information

Chemical Name:(1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate
CAS No.:1242441-17-3
Molecular Formula:C₂₁H₂₀ClN₃O₂S
Molecular Weight:413.928
Hs Code.:

Synonyms:(1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Suppliers and Price of (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

There total 5 articles about (1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 40771-41-3
2-mercapto-5-chloro-pyridine

: 1242441-05-9
ethyl (1S,2S)-2-[4-(5-iodo-1-methyl-1H-imidazol-4-yl)phenyl]cyclopropanecarboxylate

: 1242441-17-3
(1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: With potassium carbonate; copper(l) iodide; In 1,2-dimethoxyethane; at 80 ℃; Inert atmosphere;

Reference yield:

: 875479-34-8
ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1242441-17-3
(1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide; zinc(II) chloride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

1.2: 4 h / Reflux

2.1: N-iodo-succinimide / dichloromethane / 16 h / 20 °C

3.1: potassium carbonate; copper(l) iodide / isopropyl alcohol / 16 h / 80 °C / Inert atmosphere

With N-iodo-succinimide; copper(l) iodide; ethylmagnesium bromide; potassium carbonate; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol;
DOI:10.1021/ml4000996

Reference yield:

: 1242441-06-0
(1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

: 1242441-17-3
(1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodo-succinimide / dichloromethane / 16 h / 20 °C

2: potassium carbonate; copper(l) iodide / isopropyl alcohol / 16 h / 80 °C / Inert atmosphere

With N-iodo-succinimide; copper(l) iodide; potassium carbonate; In dichloromethane; isopropyl alcohol;
DOI:10.1021/ml4000996