(1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Base Information

Chemical Name:(1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate
CAS No.:1242441-06-0
Molecular Formula:C₁₆H₁₈N₂O₂
Molecular Weight:270.331
Hs Code.:

Synonyms:(1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

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Chemical Property of (1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

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Technology Process of (1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

There total 2 articles about (1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 875479-34-8
ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 71759-87-0
4-iodo-1-methyl-1H-imidazole

: 1242441-06-0
(1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: 4-iodo-1-methyl-1H-imidazole; With ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.5h;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 1h;

ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; for 4h; Reflux;

Reference yield:

: 2039-82-9
1-bromo-4-ethenyl-benzene

: 1242441-06-0
(1S,2S)-ethyl 2-(4-(1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2′-isopropylidenebis[(4R)-4-tert-butyl-2-oxazoline]; copper(I) trifluoromethanesulfonate benzene / tert-butyl methyl ether / 0 °C / Inert atmosphere

2.1: ethylmagnesium bromide; zinc(II) chloride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

2.2: 4 h / Reflux

With copper(I) trifluoromethanesulfonate benzene; ethylmagnesium bromide; 2,2′-isopropylidenebis[(4R)-4-tert-butyl-2-oxazoline]; zinc(II) chloride; In tetrahydrofuran; diethyl ether; tert-butyl methyl ether;
DOI:10.1021/ml4000996