C₁₂H₁₄ClNO₂

Base Information

• Chemical Name: C₁₂H₁₄ClNO₂
• CAS No.: 187386-90-9
• Molecular Formula: C₁₂H₁₄ClNO₂
• Molecular Weight: 239.702
• Mol file: 187386-90-9.mol

Synonyms:C₁₂H₁₄ClNO₂

Chemical Property of C₁₂H₁₄ClNO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₄ClNO₂

There total 1 articles about C₁₂H₁₄ClNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl acetoacetate (141-97-9) + 4-chloro-aniline (106-47-8) → C12H14ClNO2 (187386-90-9)

Guidance literature:

With acetic acid; In benzene; at 100 ℃; for 24h; Dean-Stark;

DOI:10.2174/1570180815666171212143339

Reference yield: 75.0%

C12H14ClNO2 (187386-90-9) → 6-chloro-2-methyl-quinolin-4-ol (15644-86-7)

Guidance literature:

In diphenylether; at 240 ℃; for 1h; Dean-Stark;

DOI:10.2174/1570180815666171212143339

Reference yield:

C12H14ClNO2 (187386-90-9) → 8-chloro-4-methyl-2-[(4-methylphenyl)methyl][1,3]oxazolo[4,5-c]quinoline (1353579-67-5)

Guidance literature:

Multi-step reaction with 5 steps

1: diphenylether / 1 h / 240 °C

2: nitric acid; propionic acid / 2.33 h / 110 °C

3: iron; ammonium chloride / ethanol; water / Reflux

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5: phosphorus pentoxide / pyridine / 5 h / Reflux

With phosphorus pentoxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; nitric acid; iron; ammonium chloride; propionic acid; N-ethyl-N,N-diisopropylamine; In pyridine; diphenylether; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201100309

upstream raw materials:

ethyl acetoacetate

4-chloro-aniline

Downstream raw materials:

C₁₈H₁₄ClN₃S

C₂₀H₁₈ClN₃S

C₁₈H₁₂Cl₂N₂OS

C₁₈H₁₃ClN₂S