3-((S)-3-cyclohexenyl-1-((S)-2-(hydroxymethyl)yrrolidin-1-yl)prop-2-ynyl)benzaldehyde

Base Information

• Chemical Name: 3-((S)-3-cyclohexenyl-1-((S)-2-(hydroxymethyl)yrrolidin-1-yl)prop-2-ynyl)benzaldehyde
• CAS No.: 1133970-61-2
• Molecular Formula: C₂₁H₂₅NO₂
• Molecular Weight: 323.435
• Mol file: 1133970-61-2.mol

Synonyms:3-((S)-3-cyclohexenyl-1-((S)-2-(hydroxymethyl)yrrolidin-1-yl)prop-2-ynyl)benzaldehyde

Chemical Property of 3-((S)-3-cyclohexenyl-1-((S)-2-(hydroxymethyl)yrrolidin-1-yl)prop-2-ynyl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((S)-3-cyclohexenyl-1-((S)-2-(hydroxymethyl)yrrolidin-1-yl)prop-2-ynyl)benzaldehyde

There total 1 articles about 3-((S)-3-cyclohexenyl-1-((S)-2-(hydroxymethyl)yrrolidin-1-yl)prop-2-ynyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-ethenylcyclohexene (931-49-7) + Isophthalaldehyde (626-19-7) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → 3-((S)-3-cyclohexenyl-1-((S)-2-(hydroxymethyl)yrrolidin-1-yl)prop-2-ynyl)benzaldehyde (1133970-61-2)

Guidance literature:

With [Au(ppy)Cl₂]; In water; at 40 ℃; for 24h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.jorganchem.2008.12.008

Reference yield: 87.0%

3-((S)-3-cyclohexenyl-1-((S)-2-(hydroxymethyl)yrrolidin-1-yl)prop-2-ynyl)benzaldehyde (1133970-61-2) → C16H16O

Guidance literature:

With silver nitrate; In acetonitrile; at 70 ℃; for 0.333333h; enantioselective reaction; Microwave irradiation;

DOI:10.1021/acs.orglett.9b02514

Reference yield:

3-((S)-3-cyclohexenyl-1-((S)-2-(hydroxymethyl)yrrolidin-1-yl)prop-2-ynyl)benzaldehyde (1133970-61-2) → C21H21NO3

Guidance literature:

Multi-step reaction with 2 steps

1: silver nitrate / acetonitrile / 0.33 h / 70 °C / Microwave irradiation

2: water / 4 h / 40 °C

With silver nitrate; In water; acetonitrile; 2: |Diels-Alder Cycloaddition;

DOI:10.1021/acs.orglett.9b02514

upstream raw materials:

1-ethenylcyclohexene

Isophthalaldehyde

(S)-1-Pyrrolidin-2-yl-methanol