(S)-(+)-γ-(methoxymethyl)-α-(phenylthio)-γ-butyrolactone

Base Information

• Chemical Name: (S)-(+)-γ-(methoxymethyl)-α-(phenylthio)-γ-butyrolactone
• CAS No.: 96845-46-4
• Molecular Formula: C₁₂H₁₄O₃S
• Molecular Weight: 238.307
• Mol file: 96845-46-4.mol

Synonyms:(S)-(+)-γ-(methoxymethyl)-α-(phenylthio)-γ-butyrolactone

Chemical Property of (S)-(+)-γ-(methoxymethyl)-α-(phenylthio)-γ-butyrolactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(+)-γ-(methoxymethyl)-α-(phenylthio)-γ-butyrolactone

There total 2 articles about (S)-(+)-γ-(methoxymethyl)-α-(phenylthio)-γ-butyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxymethyl-4,5-dihydrofuranone (10374-51-3) → (S)-(+)-γ-(methoxymethyl)-α-(phenylthio)-γ-butyrolactone (96845-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium hydride / 1.) DMF, RT, 1 h, 2.) RT, 2 h

2: 1.) lithium diisopropylamide, 2.) hexamethylphosphoramide / 1.) hexane, tetrahydrofuran, -78 deg C, 1 h, 2.) -78 deg c, 40 min

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; lithium diisopropyl amide;

DOI:10.1021/jo00215a034

Reference yield:

(S)-(+)-γ-(methoxymethyl)-γ-butyrolactone (96845-45-3,261911-63-1) + diphenyldisulfane (882-33-7) → (S)-(+)-γ-(methoxymethyl)-α-(phenylthio)-γ-butyrolactone (96845-46-4)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) hexane, tetrahydrofuran, -78 deg C, 1 h, 2.) -78 deg c, 40 min;

DOI:10.1021/jo00215a034

Reference yield: 98.0%

(S)-(+)-γ-(methoxymethyl)-α-(phenylthio)-γ-butyrolactone (96845-46-4) → (S)-3-Benzenesulfinyl-5-methoxymethyl-dihydro-furan-2-one (96845-47-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1021/jo00215a034

upstream raw materials:

(S)-(+)-γ-(methoxymethyl)-γ-butyrolactone

diphenyldisulfane

5-hydroxymethyl-4,5-dihydrofuranone

Downstream raw materials:

(S)-3-Benzenesulfinyl-5-methoxymethyl-dihydro-furan-2-one

4β-<2-(1,2-dihydro-4-methoxybenzocyclobutenyl)ethyl>-4,5-dihydro-5α-(methoxymethyl)-3-<(phenylthio)-methylene>furan-2(3H)one