1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone

Base Information

• Chemical Name: 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone
• CAS No.: 220615-62-3
• Molecular Formula: C₂₄H₂₈N₂O₄S
• Molecular Weight: 440.563
• Mol file: 220615-62-3.mol

Synonyms:1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone

Chemical Property of 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone

There total 3 articles about 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-butoxyphenylboronic acid (105365-51-3) + 3-(3-(4-bromophenylsulfanyl)-2-oxopropyl)-5,5-dimethylimidazolidine-2,4-dione (220615-61-2) → 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone (220615-62-3)

Guidance literature:

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 90 ℃; for 3h;

DOI:10.1021/jm0103920

Reference yield:

para-bromobenzenethiol (106-53-6) → 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone (220615-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 1 h / -5 °C

2: aq. NaOH / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 3 h / 90 °C

With sodium hydroxide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0103920

Reference yield:

3-(3-bromo-2-oxopropyl)-5,5-dimethylimidazolidine-2,4-dione (220616-31-9) → 1-((4'-butoxy(1,1'-biphenyl)-4-yl)thio)-3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-propanone (220615-62-3)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 1 h / -5 °C

2: aq. NaOH / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 3 h / 90 °C

With sodium hydroxide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0103920

upstream raw materials:

4-butoxyphenylboronic acid

3-(3-(4-bromophenylsulfanyl)-2-oxopropyl)-5,5-dimethylimidazolidine-2,4-dione

para-bromobenzenethiol

3-(3-bromo-2-oxopropyl)-5,5-dimethylimidazolidine-2,4-dione