Diphenyl-acetic acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Diphenyl-acetic acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
• CAS No.: 97204-94-9
• Molecular Formula: C₃₇H₃₄N₅O₈PS
• Molecular Weight: 739.745
• Mol file: 97204-94-9.mol

Synonyms:Diphenyl-acetic acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Chemical Property of Diphenyl-acetic acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diphenyl-acetic acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

There total 1 articles about Diphenyl-acetic acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-4-methylphenyl-O,O-bis(1-benzotriazolyl)phosphorothioate (97204-93-8) + 3'-O-diphenylacetyl thymidine (80817-57-8) → Diphenyl-acetic acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (97204-94-9)

Guidance literature:

With pyridine; In 1,4-dioxane; at 20 ℃; for 0.25h; Product distribution; Var_. nucleosides;

DOI:10.1016/S0040-4039(00)61968-8

Reference yield:

Diphenyl-acetic acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (97204-94-9) → thymidine 5'-phosphate (365-07-1,15108-71-1,60363-32-8,96744-88-6,132696-16-3,143838-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: I₂, H₂o / 0.08 h

2: H₂O / basic

With water; iodine;

DOI:10.1016/S0040-4039(00)61968-8

Reference yield:

Diphenyl-acetic acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (97204-94-9) → Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-phosphonooxymethyl-tetrahydro-furan-3-yl ester (97204-96-1)

Guidance literature:

With water; iodine; for 0.0833333h;

DOI:10.1016/S0040-4039(00)61968-8

upstream raw materials:

S-4-methylphenyl-O,O-bis(1-benzotriazolyl)phosphorothioate

3'-O-diphenylacetyl thymidine

Downstream raw materials:

Diphenyl-acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-phosphonooxymethyl-tetrahydro-furan-3-yl ester

Diphenyl-acetic acid (2R,3S,5R)-2-(hydroxy-p-tolylsulfanyl-phosphoryloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

C₂₄H₂₆N₂O₁₂P₂

thymidine 5'-phosphate