Pamapimod

Base Information

Chemical Name:Pamapimod
CAS No.:449811-01-2
Molecular Formula:C19H20 F2 N4 O4
Molecular Weight:406.389
Hs Code.:2933998090
UNII:8S2C9V11K4
ChEMBL ID:CHEMBL1090089
DSSTox Substance ID:DTXSID90963312
NCI Thesaurus Code:C90996
Pharos Ligand ID:171LZC4Y7XCH
Wikidata:Q27162644
Mol file:449811-01-2.mol

Synonyms:pamapimod

Suppliers and Price of Pamapimod

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Pamapimod
1mg
$ 744.00

TRC
Pamapimod
5mg
$ 855.00

DC Chemicals
Pamapimod（R-1503） >98%
1 g
$ 1800.00

ChemScene
Pamapimod 99.92%
25mg
$ 1200.00

ChemScene
Pamapimod 99.92%
50mg
$ 2040.00

ChemScene
Pamapimod 99.92%
10mg
$ 600.00

Cayman Chemical
Pamapimod ≥98%
5mg
$ 856.00

Cayman Chemical
Pamapimod ≥98%
500μg
$ 107.00

Cayman Chemical
Pamapimod ≥98%
1mg
$ 193.00

ApexBio Technology
Pamapimod(R-1503,Ro4402257)
10mg
$ 1024.00

Total 26 raw suppliers

Chemical Property of Pamapimod

Chemical Property:

PSA：112.73000
LogP:1.36620
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:406.14526146
Heavy Atom Count:29
Complexity:591

Purity/Quality:

99%, ^*data from raw suppliers

Pamapimod ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC(CCO)CCO
Recent EU Clinical Trials:An 8-week double-blind, randomized, placebo-controlled, phase II study evaluating the effects of oral pamapimod 150 mg with pioglitazone 10 mg daily on COVID-19 development in hospitalized patients infected with SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2)
Uses A selective inhibitor of the α-isoform of p38 MAP kinase A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.

Technology Process of Pamapimod

There total 8 articles about Pamapimod which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 449808-50-8
6-(2,4-difluorophenoxy)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

: 1032451-78-7
3-trimethylsilanyloxy-1-(2-trimethylsilanyloxyethyl)propylamine

: 449811-01-2
[14C]-Pamapimod

Guidance literature:: 6?(2,4?difluorophenoxy)?8?methyl?2?(methylsulfonyl)pyrido[2,3?d]pyrimidin?7(8H)?one; 3-trimethylsilanyloxy-1-(2-trimethylsilanyloxyethyl)propylamine; With N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran; Reflux;

With potassium dihydrogenphosphate; water; In tert-butyl methyl ether;
DOI:10.1021/jm101423y

Reference yield:

: 449811-12-5
6?(2,4?difluorophenoxy)?8?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one

: 449811-01-2
[14C]-Pamapimod

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid; dihydrogen peroxide / dichloromethane; water / 38 °C

2: N,O-bis-(trimethylsilyl)-acetamide / tetrahydrofuran / Reflux

With formic acid; N,O-bis-(trimethylsilyl)-acetamide; dihydrogen peroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm101423y

Reference yield:

: 17759-30-7
(4-methylamino-2-methylsulfanyl-pyrimidin-5-yl)-methanol

: 449811-01-2
[14C]-Pamapimod

Guidance literature:: Multi-step reaction with 4 steps

1: manganese(IV) oxide / dichloromethane / 24 h

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 120 °C

3: formic acid; dihydrogen peroxide / dichloromethane; water / 38 °C

4: N,O-bis-(trimethylsilyl)-acetamide / tetrahydrofuran / Reflux

With manganese(IV) oxide; formic acid; N,O-bis-(trimethylsilyl)-acetamide; dihydrogen peroxide; potassium carbonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water;
DOI:10.1021/jm101423y