6-(2,4-Difluorophenoxy)-8-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one

Base Information

• Chemical Name: 6-(2,4-Difluorophenoxy)-8-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one
• CAS No.: 449811-12-5
• Molecular Formula: C₁₅H₁₁F₂N₃O₂S
• Molecular Weight: 335.334
• Mol file: 449811-12-5.mol

Synonyms:6?(2,4?difluorophenoxy)?8?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one

Chemical Property of 6-(2,4-Difluorophenoxy)-8-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one

Chemical Property:

• Melting Point: 175-177°C
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform, DMSO

Purity/Quality:

99% ^*data from raw suppliers

6-(2,4-Difluorophenoxy)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-(2,4-Difluorophenoxy)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one is an intermediate in the synthesis of Pamapimod (P167500), a selective inhibitor of the α-isoform of p38 MAP kinase.

Technology Process of 6-(2,4-Difluorophenoxy)-8-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one

There total 9 articles about 6-(2,4-Difluorophenoxy)-8-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

6-(2,4-difluorophenoxy)-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one (1280218-22-5) + methyl iodide (74-88-4) → 6?(2,4?difluorophenoxy)?8?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one (449811-12-5)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; for 2h;

Reference yield: 69.0%

methyl 2,4-difluorophenoxyacetate (449811-63-6) + 4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde (185040-32-8) → 6?(2,4?difluorophenoxy)?8?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one (449811-12-5)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 18h;

DOI:10.1021/jm101423y

Reference yield: 55.0%

2,4-difluorophenol (367-27-1) + bromoacetic acid methyl ester (96-32-2) + 4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde (185040-32-8) → 6?(2,4?difluorophenoxy)?8?methyl?2?(methylthio)pyrido[2,3?d]pyrimidin?7(8H)?one (449811-12-5)

Guidance literature:

2,4-difluorophenol; bromoacetic acid methyl ester; With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 6h;

4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde; With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 12h;

DOI:10.1016/j.bmcl.2015.11.099

upstream raw materials:

methyl 2,4-difluorophenoxyacetate

4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde

(4-methylamino-2-methylsulfanyl-pyrimidin-5-yl)-methanol

4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

Downstream raw materials:

6-(2,4-difluorophenoxy)-8-methyl-2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7(8H)-one

6-(2,4-difluorophenoxy)-8-methyl-2-methylamino-8H-pyrido[2,3-d]pyrimidin-7-one

6-(2,4-difluorophenoxy)-2-isopropylamino-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

6-(2,4-difluorophenoxy)-8-methyl-2-[(S)-(tetrahydrofuran-3-yl)amino]-8H-pyrido[2,3-d]pyrimidin-7-one