Technology Process of C31H53NO9P(1+)
There total 4 articles about C31H53NO9P(1+) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phosphoric acid di-tert-butyl 2-hydroxymethylphenyl ester;
With
1,2,2,6,6-pentamethylpiperidine; methanesulfonyl chloride;
In
dichloromethane;
at 22 ℃;
for 2h;
C24H45NO5;
With
sodium iodide;
In
acetonitrile;
for 18h;
With
hydrogenchloride;
In
1,4-dioxane; dichloromethane;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 48 h
1.2: 18 h
1.3: 6 h
2.1: dmap; pivaloyl chloride; triethylamine / dichloromethane / 0 - 22 °C
2.2: 4 h
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h
4.1: 1,2,2,6,6-pentamethylpiperidine; methanesulfonyl chloride / dichloromethane / 2 h / 22 °C
4.2: 18 h
4.3: 2 h
With
1,2,2,6,6-pentamethylpiperidine; dmap; tetrabutyl ammonium fluoride; hydrogen; pivaloyl chloride; methanesulfonyl chloride; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 18 h / 0 °C
1.2: -78 - 20 °C
2.1: 1,2,2,6,6-pentamethylpiperidine; methanesulfonyl chloride / dichloromethane / 2 h / 22 °C
2.2: 18 h
2.3: 2 h
With
1,2,2,6,6-pentamethylpiperidine; dmap; methanesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; dichloromethane;
