Sodelglitazar

Base Information

Chemical Name:Sodelglitazar
CAS No.:447406-78-2
Molecular Formula:C23H21F4NO3S2
Molecular Weight:499.55
Hs Code.:
UNII:6G973E04VI
DSSTox Substance ID:DTXSID90196289
Wikipedia:Sodelglitazar
Wikidata:Q15708299
NCI Thesaurus Code:C75193
ChEMBL ID:CHEMBL2104984
Mol file:447406-78-2.mol

Synonyms:Sodelglitazar;447406-78-2;Sodelglitazar [USAN:INN];UNII-6G973E04VI;GW677954;Sodelglitazar [USAN];6G973E04VI;2-(4-(((2-(2-Fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)-2-methylpropanoic acid;Sodelglitazar (USAN);GW 677954;GW-677954;2-[4-[[[2-[2-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methyl]sulfanyl]-2-methylphenoxy]-2-methylpropanoic acid;Propanoic acid, 2-(4-(((2-(2-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-5-thiazolyl)methyl)thio)-2-methylphenoxy)-2-methyl-;D01JGG;SODELGLITAZAR [INN];SCHEMBL4822839;CHEMBL2104984;DTXSID90196289;AKOS040749540;2-[4-[[2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]-2-methylpropanoic acid;FT-0743554;D06647;Q15708299;2-{4-[({2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy-}-2-methylpropanoic acid;2-{4-[({2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methyl)thio]-2-methylphenoxy}-2-methylpropanoic acid

Suppliers and Price of Sodelglitazar

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of Sodelglitazar

Chemical Property:

Boiling Point:588.0±60.0 °C(Predicted)
PKA:3.27±0.10(Predicted)
PSA：112.96000
Density:1.40
LogP:7.11910
XLogP3:6.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:7
Exact Mass:499.08989853
Heavy Atom Count:33
Complexity:681

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=C(C=C(C=C3)C(F)(F)F)F)C)OC(C)(C)C(=O)O
Recent ClinicalTrials:Study In People With Type 2 Diabetes
Recent EU Clinical Trials:A Multicenter, Randomized, Double-Blind, Double-Dummy, Parallel-Group, Placebo-Controlled, Study To Evaluate Efficacy, Safety And Tolerability Of Oral GW677954 Capsules (2.5, 5, 10, 15 And 20 Mg Once A Day) As A Monotherapy (Diet and/or
Uses Treatment of type 2 diabetes.

Technology Process of Sodelglitazar

There total 5 articles about Sodelglitazar which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 447406-50-0
4-[[[2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenol

: 2052-01-9
2-bromo-2-methylpropionic acid

: 447406-78-2
Sodelglitazar

Guidance literature:: 4-[[[2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenol; With sodium hydroxide; In butanone; at 50 ℃; for 1h; Inert atmosphere; Large scale reaction;

2-bromo-2-methylpropionic acid; In butanone; at 50 ℃; for 3h; Large scale reaction;
DOI:10.1021/op8002294

Reference yield: 70.0%

: 447406-50-0
4-[[[2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenol

: 57-15-8
1,1,1-trichloro-2-methyl-2-propanol

: 447406-78-2
Sodelglitazar

Guidance literature:: 4-[[[2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenol; With sodium hydroxide; In acetone; at 32 ℃; for 3h;

1,1,1-trichloro-2-methyl-2-propanol; In acetone; at 36 - 38 ℃; for 1h;

With hydrogenchloride; water; In methyl tert-butyl ether (MTBE); acetone; at 25 ℃; Product distribution / selectivity;

Reference yield: 66.0%

: 5-[[[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphenyl]thio]methyl]-2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methylthiazole

: 57-15-8
1,1,1-trichloro-2-methyl-2-propanol

: 447406-78-2
Sodelglitazar

Guidance literature:: 5-[[[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methylphenyl]thio]methyl]-2-[2-fluoro-4-(trifluoromethyl)phenyl]-4-methylthiazole; With sodium hydroxide; In acetone; at 30 ℃; for 0.75h;

1,1,1-trichloro-2-methyl-2-propanol; In acetone; at 30 - 40 ℃;

With hydrogenchloride; water; pH=1; Product distribution / selectivity;