2-Bromo-2-methylpropionic acid

Base Information Edit

Chemical Name:2-Bromo-2-methylpropionic acid
CAS No.:2052-01-9
Deprecated CAS:280757-31-5
Molecular Formula:C4H7BrO2
Molecular Weight:167.002
Hs Code.:29156000
European Community (EC) Number:218-139-2
NSC Number:41213
UNII:821P2R6B0A
DSSTox Substance ID:DTXSID8062151
Nikkaji Number:J1.795G
Wikidata:Q27269291
Mol file:2052-01-9.mol

Synonyms:Isobutyricacid, a-bromo- (4CI);Propionic acid,2-bromo-2-methyl- (6CI,7CI,8CI);2-Bromo-2-methylpropanoic acid;2-Bromoisobutyric acid;Bromoisobutyric acid;Isobromobutyric acid;NSC41213;a-Bromo-a-methylpropionic acid;a-Bromoisobutyric acid;

Suppliers and Price of 2-Bromo-2-methylpropionic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Bromoisobutyric Acid
250g
$ 150.00

TCI Chemical
2-Bromoisobutyric Acid >98.0%(GC)
500g
$ 218.00

TCI Chemical
2-Bromoisobutyric Acid >98.0%(GC)
25g
$ 27.00

TCI Chemical
2-Bromoisobutyric Acid >98.0%(GC)
100g
$ 70.00

Sigma-Aldrich
2-Bromo-2-methylpropionic acid 98%
100g
$ 81.30

Sigma-Aldrich
2-Bromo-2-methylpropionic acid 98%
25g
$ 30.60

Oakwood
2-Bromo-2-methylpropionic acid 98%
100g
$ 60.00

Oakwood
2-Bromo-2-methylpropionic acid 98%
1g
$ 10.00

Medical Isotopes, Inc.
2-Bromoisobutyric Acid
25 g
$ 675.00

Medical Isotopes, Inc.
2-Bromoisobutyric Acid
10 g
$ 610.00

Total 116 raw suppliers

Chemical Property of 2-Bromo-2-methylpropionic acid Edit

Chemical Property:

Appearance/Colour:white powder
Vapor Pressure:0.147mmHg at 25°C
Melting Point:44-47 °C(lit.)
Refractive Index:1.495
Boiling Point:198.999 °C at 760 mmHg
PKA:2.91±0.10(Predicted)
Flash Point:78.805 °C
PSA：37.30000
Density:1.631 g/cm³
LogP:1.24450
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Water Solubility.:Soluble in alcohol and ether. Slightly soluble in water.
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:165.96294
Heavy Atom Count:7
Complexity:87.7

Purity/Quality:

99% ^*data from raw suppliers

2-Bromoisobutyric Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): C
Hazard Codes:C
Statements: 34
Safety Statements: 26-36/37/39-45-25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C(=O)O)Br
Uses 2-Bromo-2-methylpropionic acid is used in the Herceptin functionalization of polyhedral oligomeric silsesquioxane-conjugated oligomers-silica /iron oxide nanoparticles for tumor cell sorting. 2-Bromoisobutyric acid is used in the synthesis of dextran macroinitiator for atom transfer radical polymerization (ATRP) by partial esterification of hydroxyl group of the polysaccharide. The multifunctional silica colloids were prepared by coating them with 2-bromo-2-methylpropionic acid stabilized quantum dots.

Technology Process of 2-Bromo-2-methylpropionic acid

There total 10 articles about 2-Bromo-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 79-31-2
isobutyric Acid

: 2052-01-9
2-bromo-2-methylpropionic acid

Guidance literature:: With N-Bromosuccinimide; sulfuric acid; In trifluoroacetic acid; at 85 ℃; for 16h;
DOI:10.1016/S0040-4039(98)02204-7

Reference yield: 66.0%

: 79-31-2
isobutyric Acid

: 630-51-3
tetramethyl succinic acid

: 2052-01-9
2-bromo-2-methylpropionic acid

Guidance literature:: isobutyric Acid; With lithium diisopropyl amide; In tetrahydrofuran; at 0 - 40 ℃; Inert atmosphere;

With N,N-diethyl-N-bromoamine; In tetrahydrofuran; at 20 - 25 ℃; for 2h; Inert atmosphere;
DOI:10.1134/S1070363216110116