(S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid

Base Information

Chemical Name:(S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid
CAS No.:123593-54-4
Molecular Formula:C₂₈H₃₈Cl₂N₄O₈
Molecular Weight:629.538
Hs Code.:

(S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid

Synonyms:(S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid

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Chemical Property of (S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid

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Technology Process of (S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid

There total 4 articles about (S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 123593-53-3
(S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid 2-trimethylsilanyl-ethyl ester

: 123593-54-4
(S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid

Guidance literature:: With tetrabutyl ammonium fluoride;
DOI:10.1021/ja00206a021

Reference yield:

: 123593-51-1
(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid

: 123593-54-4
(S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole

2: 1.) SnCl₂, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole / 1.) MeOH

3: 99 percent / n-Bu₄NF

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride;
DOI:10.1021/ja00206a021

Reference yield:

: 123593-50-0
(R)-3-[(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-bromo-3-hydroxy-propionyl]-4-benzyl-oxazolidin-2-one

: 123593-54-4
(S)-2-{(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-hydroxy-propionylamino}-3-cyano-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaN₃, 2.) LiOOH / 1.) DMSO

2: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole

3: 1.) SnCl₂, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole / 1.) MeOH

4: 99 percent / n-Bu₄NF

With sodium azide; lithium hydroperoxide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride;
DOI:10.1021/ja00206a021