(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid

Base Information

Chemical Name:(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid
CAS No.:123593-51-1
Molecular Formula:C₁₂H₁₁Cl₂N₃O₄
Molecular Weight:332.143
Hs Code.:

Synonyms:(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid

Chemical Property:

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Technology Process of (2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid

There total 1 articles about (2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123593-50-0
(R)-3-[(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-bromo-3-hydroxy-propionyl]-4-benzyl-oxazolidin-2-one

: 123593-51-1
(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid

Guidance literature:: With sodium azide; lithium hydroperoxide; Yield given. Multistep reaction; 1.) DMSO;
DOI:10.1021/ja00206a021

Reference yield: 84.0%

: 123593-71-5
L-β-Cyanoalanine (trimethylsilyl)ethyl ester

: 123593-51-1
(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid

: (S)-2-[(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionylamino]-3-cyano-propionic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1021/ja00206a021

Reference yield:

: 123593-51-1
(2R,3R)-3-(4-Allyloxy-3,5-dichloro-phenyl)-2-azido-3-hydroxy-propionic acid

: 123593-55-5
{(R)-1-[(1R,2R)-1-((S)-2-Cyano-1-{[(R)-(3,5-dibromo-4-hydroxy-phenyl)-methylcarbamoyl-methyl]-carbamoyl}-ethylcarbamoyl)-2-(3,5-dichloro-4-hydroxy-phenyl)-2-hydroxy-ethylcarbamoyl]-3-methyl-butyl}-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole

2: 1.) SnCl₂, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole / 1.) MeOH

3: 99 percent / n-Bu₄NF

4: 1.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, hydroxybenzotriazole, 2.) Bu₃SnH / 2.) Pd(PPh₃)2Cl₂

With tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tin(ll) chloride; bis-triphenylphosphine-palladium(II) chloride;
DOI:10.1021/ja00206a021