(R)-3-butanamidobutanoic acid tert-butyl ester

Base Information

• Chemical Name: (R)-3-butanamidobutanoic acid tert-butyl ester
• CAS No.: 1067647-39-5
• Molecular Formula: C₁₂H₂₃NO₃
• Molecular Weight: 229.32
• Mol file: 1067647-39-5.mol

Synonyms:(R)-3-butanamidobutanoic acid tert-butyl ester

Chemical Property of (R)-3-butanamidobutanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-butanamidobutanoic acid tert-butyl ester

There total 2 articles about (R)-3-butanamidobutanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

butanoic acid ethyl ester (105-54-4) + 3(R,S)-Methyl-β-alanine tert-butyl ester (120686-16-0,158849-23-1) → (R)-3-butanamidobutanoic acid tert-butyl ester (1067647-39-5) + tert-butyl (R)-3-amino-3-methyl-propionate (120686-16-0,158849-23-1) + tert-butyl (3S)-3-aminobutanoate (161105-54-0,158849-23-1)

Guidance literature:

With lipase A from candida antarctica; at 47 ℃; for 29h; Overall yield = 38 %; stereoselective reaction; Enzymatic reaction;

DOI:10.1002/cctc.201501381

Reference yield:

acetic acid tert-butyl ester (540-88-5) → (R)-3-butanamidobutanoic acid tert-butyl ester (1067647-39-5) + tert-butyl (R)-3-amino-3-methyl-propionate (120686-16-0,158849-23-1) + tert-butyl (3S)-3-aminobutanoate (161105-54-0,158849-23-1)

Guidance literature:

Multi-step reaction with 2 steps

1: perchloric acid / 20 °C

2: lipase A from candida antarctica / 29 h / 47 °C / Enzymatic reaction

With perchloric acid; lipase A from candida antarctica;

DOI:10.1002/cctc.201501381

Reference yield:

(R)-3-butanamidobutanoic acid tert-butyl ester (1067647-39-5) → (R)-3-aminobutanoic acid (3775-73-3)

Guidance literature:

With hydrogenchloride; for 16h; Heating;

DOI:10.1016/j.tetasy.2008.07.017

upstream raw materials:

acetic acid tert-butyl ester

butanoic acid ethyl ester

3(R,S)-Methyl-β-alanine tert-butyl ester

Downstream raw materials:

(R)-3-aminobutanoic acid