3775-73-3

Basic information

• Product Name: (R)-3-AMINOBUTYRIC ACID
• Synonyms: (R)-B-AMINOBUTYRIC ACID;RARECHEM LK HD C012;(R)-3-AMINOBUTYRIC ACID;(R)-3-aminobutanoic acid;D-3-Abu-OH;L-3-Abu-OH;(R)-beta-homo-alanine;(R)-HOMO-BETA-ALANINE
• CAS NO: 3775-73-3
• Molecular Formula: C₄H₉NO₂
• Molecular Weight: 103.12
• Mol File: 3775-73-3.mol
• Article Data: 24

Chemical Properties

• Melting Point: 215-216 °C
• Boiling Point: 223.6 °C at 760 mmHg
• Flash Point: 89 °C
• Appearance: /
• Density: 1.105 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Methanol (Slightly), Water (Slightly, Sonicated)
• PKA: 3.67±0.12(Predicted)
• CAS DataBase Reference: (R)-3-AMINOBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-AMINOBUTYRIC ACID(3775-73-3)
• EPA Substance Registry System: (R)-3-AMINOBUTYRIC ACID(3775-73-3)

Safety Data

• Hazardous Substances Data: 3775-73-3(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

(R)-3-Aminobutanoic Acid is used in preparation of fused ring Pyrimidone derivatives for use in the treatment of HBV infection or of HBV-induced. diseases

Upstream product

• 67843-72-5 (R)-3-(((benzyloxy)carbonyl)amino)butanoic acid 
• 132540-67-1 (R)-3-(dibenzylamino)butanoic acid 
• 623-43-8 crotonic acid methyl ester 
• 120686-16-0 tert-butyl (R)-3-amino-3-methyl-propionate 
• 1067647-39-5 (R)-3-butanamidobutanoic acid tert-butyl ester 
• 107-93-7 (E)-but-2-enoic acid 
• 95503-53-0 3-[Hydroxy-((S)-1-phenyl-ethyl)-amino]-butyric acid methyl ester 
• 394220-59-8 N-p-methoxybenzyl-3-methylisoxazolidin-5-one 
• 147228-34-0 (3R)-3-(tosylamino)butanoic acid 
• 64838-60-4 (3R,1'S)-3-<(1'-phenylethyl)amino>butanoic acid methyl ester 
• 141632-86-2 (1'S,6R)-1-benzyloxycarbonyl-3-(1'-phenyleth-1'-yl)-6-methylperihydropyrimidin-4-one 
• 134430-94-7 benzyl (3R,αR)-3-(N-benzyl-N-α-methylbenzylamino)butanoate 
• 21948-18-5 (S)-3-amino-4-methylsulfanyl-butyric acid 

Downstream Products

• 113034-29-0 (R)-3-(benzoylamino)butanoic acid 
• 67843-72-5 (R)-3-(((benzyloxy)carbonyl)amino)butanoic acid 
• 120686-16-0 tert-butyl (R)-3-amino-3-methyl-propionate 
• 1392843-06-9 (R)-3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-butyric acid 
• 61477-40-5 (R)-3-amino-1-butanol 
• 159991-23-8 (R)-3-((tert-butoxycarbonyl)amino)butanoic acid 
• 139243-54-2 (R)-3-aminobutanoic acid methyl ester hydrochloride 
• 6078-06-4 (R)-methyl 3-aminobutanoate hydrochloride 

Relevant articles and documents

Michael-type addition of phthalimide salts to chiral α,β-unsaturated imides

The synthesis of (R)-(-)-3-aminobutanoic acid starting from chiral α,β- unsaturated imide 1b is described, by means of the nucleophilic attack of several phthalimido derivatives in the presence of a Lewis acid. The reaction was studied in some details and chloromagnesium phthalimide afforded the better results with 95:5 diastereomeric ratio and 90% yield. Furthermore the resulting enolate was trapped performing the reaction in the presence of benzenesulfonyl bromide and the 2-bromo-3-phthalimido derivative 4 was obtained in good yield and high diastereoselectivity and successively transformed into the corresponding 2-azido-3-phthalimido derivative 6 by displacement of the bromide with sodium azide.

Preparation method of 3-aminopropanol or 3-aminopropionic acid derivative

The invention provides a preparation method of an optically active 3-aminopropanol or 3-aminopropionic acid derivative, and belongs to the technical field of organic synthesis. A compound having a structure as shown in a formula II and a formula III is used as a raw material, and the optically active 3-aminopropanol or 3-aminopropionic acid derivative is obtained through four basic steps, namely dehydration condensation, hydrogenation reduction, reduction and hydrolysis. The raw materials adopted in the preparation method are easy to obtain and low in cost; as a chiral phosphine-transitional metal catalyst is used in the hydrogenation reduction reaction, the optically active 3-aminopropanol or 3-aminopropionic acid derivative is efficient, high in selectivity, low in cost and suitable forlarge-scale production. Compared with existing chemical resolution and chiral introduction, the asymmetric hydrogenation synthesis method provided by the invention only produces one chiral product, ishigh in yield, and has relatively high advantages in economy and raw material utilization rate.

A optically active 3 - amino butanol and 3 - aminobutyric acid preparation method (by machine translation)

The invention discloses a method of optically active 3 - amino butanol and 3 - aminobutyric acid preparation method. Wherein optically active 3 - amino butyl alcohol preparation method comprises the following steps: in a solvent, in the borohydride reducing agent and a Lewis acid under the action of the, shown as 65 shown in the reduction reaction of compound, production like type 14 indicated by the compound. Optically active 3 - aminobutyric acid preparation method comprises the following steps: shown as 64 a compound represented by the hydrolytic reaction, production like type 65 compound of formula. Preparation method of this invention the raw material is cheap, simple operation, the process route is short, the raw material is not hazardous, high yield, produce little material waste, is beneficial for the protection of the environment, high conversion rate of raw materials, product chemical purity and high optical purity, and is easy to realize industrial. (by machine translation)