(E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)yl]-2-propen-1-one

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Chemical Name:(E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)yl]-2-propen-1-one
CAS No.:1381803-47-9
Molecular Formula:C₂₈H₃₀N₆O₃
Molecular Weight:498.585
Hs Code.:

Synonyms:(E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)yl]-2-propen-1-one

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Chemical Property of (E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)yl]-2-propen-1-one

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Technology Process of (E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)yl]-2-propen-1-one

There total 5 articles about (E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)yl]-2-propen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1381802-89-6
1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)-yl]-2-propen-1-one

: 83166-73-8
5-(3-iodo-4,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine

: 1381803-47-9
(E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)yl]-2-propen-1-one

Guidance literature:: With dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium(II); triethylamine; In N,N-dimethyl-formamide; at 90 ℃; for 8h; Reagent/catalyst; Solvent; Temperature; Time; Catalytic behavior; Inert atmosphere;
DOI:10.3390/molecules20047222

Reference yield:

: 253-52-1
PHTHALAZINE

: 1381803-47-9
(E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)yl]-2-propen-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 2.33 h / 0 °C

2: triethylamine / dichloromethane / 2.33 h / 0 °C

3: 1-ethyl-piperidine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 140 °C / Inert atmosphere; sealed tube

With 1-ethyl-piperidine; bis-triphenylphosphine-palladium(II) chloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 3: Heck reaction;
DOI:10.1016/j.ejmech.2012.05.018

Reference yield:

: C₁₂H₁₄N₂

: 1381803-47-9
(E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methyl-1-propen-1-yl)phthalazin-2(1H)yl]-2-propen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2.33 h / 0 °C

2: 1-ethyl-piperidine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 140 °C / Inert atmosphere; sealed tube

With 1-ethyl-piperidine; bis-triphenylphosphine-palladium(II) chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; 2: Heck reaction;
DOI:10.1016/j.ejmech.2012.05.018