(rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

Base Information

Chemical Name:(rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one
CAS No.:1062244-15-8
Molecular Formula:C₁₄H₁₉ClN₄O
Molecular Weight:294.784
Hs Code.:

Synonyms:(rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

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Chemical Property of (rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

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Technology Process of (rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

There total 1 articles about (rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1062244-14-7
(rac)-3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2-methyl-propanoic acid ethyl ester

: 1062244-15-8
(rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

Guidance literature:: (rac)-3-[(2-chloro-5-nitro-pyrimidin-4-yl)-cyclohexyl-amino]-2-methyl-propanoic acid ethyl ester; With iron; acetic acid; at 80 ℃; for 2h;

With ammonia; water;

Reference yield:

: 1062244-15-8
(rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

: 74-88-4
methyl iodide

: 1062244-20-5
(rac)-2-chloro-9-cyclohexyl-5,7-dimethyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 876126-60-2
4-amino-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

: 1062244-15-8
(rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

: 76-05-1
trifluoroacetic acid

: (rac)-4-(9-cyclohexyl-7-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-methoxy-N-(1-methyl-piperidin-4-yl)-benzamide trifluoroacetate

Guidance literature:: 4-amino-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide; (rac)-2-chloro-9-cyclohexyl-7-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one; With toluene-4-sulfonic acid; In isopropyl alcohol; at 180 ℃; for 1.5h; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;