L-Proline, 1-(2-ethyl-2-methyl-2H-azirin-3-yl)-, methyl ester (9CI)

Base Information

Chemical Name:L-Proline, 1-(2-ethyl-2-methyl-2H-azirin-3-yl)-, methyl ester (9CI)
CAS No.:445396-40-7
Molecular Formula:C11H18 N2 O2
Molecular Weight:210.27282
Hs Code.:
Mol file:445396-40-7.mol

Synonyms:L-Proline, 1-(2-ethyl-2-methyl-2H-azirin-3-yl)-, methyl ester (9CI)

Suppliers and Price of L-Proline, 1-(2-ethyl-2-methyl-2H-azirin-3-yl)-, methyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Proline, 1-(2-ethyl-2-methyl-2H-azirin-3-yl)-, methyl ester (9CI)

Chemical Property:

PSA：41.90000
LogP:0.57810

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Proline, 1-(2-ethyl-2-methyl-2H-azirin-3-yl)-, methyl ester (9CI)

There total 5 articles about L-Proline, 1-(2-ethyl-2-methyl-2H-azirin-3-yl)-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl (S)-N-(1-chloro-2-methylbut-1-enyl)prolinate

: 445396-40-7
methyl (S)-N-[(R/S)-2-ethyl-2-methyl-2H-azirin-3-yl]prolinate

Guidance literature:: With sodium azide; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/1522-2675(200203)85:3<885::AID-HLCA885>3.0.CO;2-Z

Reference yield:

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 445396-40-7
methyl (S)-N-[(R/S)-2-ethyl-2-methyl-2H-azirin-3-yl]prolinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

2.1: 70 percent / Lawesson reagent / toluene / 1.25 h / Heating

3.1: COCl₂; DMF / CH₂Cl₂ / 1 h / 0 - 20 °C

3.2: 1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 0.33 h / 20 °C

4.1: NaN₃ / tetrahydrofuran / 20 °C

With Lawessons reagent; sodium azide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/1522-2675(200203)85:3<885::AID-HLCA885>3.0.CO;2-Z

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 445396-40-7
methyl (S)-N-[(R/S)-2-ethyl-2-methyl-2H-azirin-3-yl]prolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: SOCl₂ / 1 h / Heating

2.1: 94 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

3.1: 70 percent / Lawesson reagent / toluene / 1.25 h / Heating

4.1: COCl₂; DMF / CH₂Cl₂ / 1 h / 0 - 20 °C

4.2: 1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 0.33 h / 20 °C

5.1: NaN₃ / tetrahydrofuran / 20 °C

With Lawessons reagent; thionyl chloride; sodium azide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/1522-2675(200203)85:3<885::AID-HLCA885>3.0.CO;2-Z