methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate

Base Information

Chemical Name:methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate
CAS No.:445396-42-9
Molecular Formula:C₂₈H₃₅N₃O₆
Molecular Weight:509.602
Hs Code.:

Synonyms:methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate

Suppliers and Price of methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate

There total 6 articles about methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1161-13-3
N-Cbz-L-Phe

: 445396-40-7
methyl (S)-N-[(R/S)-2-ethyl-2-methyl-2H-azirin-3-yl]prolinate

: 445396-42-9
methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate

Guidance literature:: In acetonitrile; at 20 ℃; for 22h;
DOI:10.1002/1522-2675(200203)85:3<885::AID-HLCA885>3.0.CO;2-Z

Reference yield:

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 445396-42-9
methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

2.1: 70 percent / Lawesson reagent / toluene / 1.25 h / Heating

3.1: COCl₂; DMF / CH₂Cl₂ / 1 h / 0 - 20 °C

3.2: 1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 0.33 h / 20 °C

4.1: NaN₃ / tetrahydrofuran / 20 °C

5.1: 90 percent / acetonitrile / 22 h / 20 °C

With Lawessons reagent; sodium azide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1002/1522-2675(200203)85:3<885::AID-HLCA885>3.0.CO;2-Z

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 445396-42-9
methyl N-[(benzyloxy)carbonyl]-(S)-phenylalanyl-(R/S)-methyl(ethyl)glycyl-(S)-prolinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: SOCl₂ / 1 h / Heating

2.1: 94 percent / Et₃N / CH₂Cl₂ / 15 h / 20 °C

3.1: 70 percent / Lawesson reagent / toluene / 1.25 h / Heating

4.1: COCl₂; DMF / CH₂Cl₂ / 1 h / 0 - 20 °C

4.2: 1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 0.33 h / 20 °C

5.1: NaN₃ / tetrahydrofuran / 20 °C

6.1: 90 percent / acetonitrile / 22 h / 20 °C

With Lawessons reagent; thionyl chloride; sodium azide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1002/1522-2675(200203)85:3<885::AID-HLCA885>3.0.CO;2-Z