(S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide

Base Information

Chemical Name:(S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide
CAS No.:98612-54-5
Molecular Formula:C₅₇H₈₅N₉O₉S₂
Molecular Weight:1104.49
Hs Code.:

(S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide

Synonyms:(S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide

Suppliers and Price of (S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide

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Chemical Property of (S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide

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Technology Process of (S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide

There total 4 articles about (S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51644-96-3
5-tert-butoxycarbonylamino-1-aminopentane

: 98612-55-6
(S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid

: 98612-54-5
(S)-1-[(4R,7S,10S,13S,16R)-13-Benzyl-7-carbamoylmethyl-20,20-bis-cyclopentylmethyl-16-(4-ethoxy-benzyl)-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; Multistep reaction; 1.) DMF;
DOI:10.1021/jm00150a003

Reference yield:

: 51644-96-3
5-tert-butoxycarbonylamino-1-aminopentane

: 98612-55-6
(S)-1-[(10R,13S,16S,19S,22R)-19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaaza-spiro[5.19]pentacosane-10-carbonyl]-pyrrolidine-2-carboxylic acid

: 98612-54-5
(S)-1-[(10R,13S,16S,19S,22R)-19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaaza-spiro[5.19]pentacosane-10-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; Yield given. Multistep reaction; 1.) DMF, room temperature, 2.) 0 deg C;
DOI:10.1021/jm00122a017

Reference yield:

: 462-94-2
1,5-diaminopentane

: 98612-54-5
(S)-1-[(10R,13S,16S,19S,22R)-19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaaza-spiro[5.19]pentacosane-10-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-pentyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.6 g / CH₂Cl₂ / Ambient temperature

2: 1.) dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate, 2.) trifluoroacetic acid / 1.) DMF, room temperature, 2.) 0 deg C

With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00122a017