Technology Process of 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1S,2S)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide
There total 13 articles about 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1S,2S)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxamide;
With
3-chloro-benzenecarboperoxoic acid;
In
1-methyl-pyrrolidin-2-one;
at 20 ℃;
for 0.666667h;
(1S,2S)-3,3-difluorocyclohexane-1,2-diamine ditrifluoroacetate;
With
N-ethyl-N,N-diisopropylamine;
In
1-methyl-pyrrolidin-2-one;
at 90 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h
1.2: 2 h
2.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 0.67 h / 20 °C
2.2: 2 h / 90 °C
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid;
In
1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hydroxide monohydrate / 1,4-dioxane; water
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2.5 h
2.2: 2 h
3.1: 3-chloro-benzenecarboperoxoic acid / 1-methyl-pyrrolidin-2-one / 0.67 h / 20 °C
3.2: 2 h / 90 °C
With
lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide;
