BAY 1101042

Base Information

Chemical Name:BAY 1101042
CAS No.:1402936-61-1
Molecular Formula:C₂₃H₂₂Cl₂F₃NO₃
Molecular Weight:488.334
Hs Code.:

Synonyms:BAY 1101042

Suppliers and Price of BAY 1101042

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of BAY 1101042

Chemical Property:

Purity/Quality:: 98%+ ^*data from raw suppliers

Safty Information:

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Hazard Codes:

MSDS Files:

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Technology Process of BAY 1101042

There total 21 articles about BAY 1101042 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1402937-56-7
tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate

: 1402936-61-1
BAY 1101042

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 50 ℃; for 12h;

Reference yield: 67.0%

: 1297550-14-1
(+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

: (3S)-3-(3-amino-4-chlorophenyl)-3-cyclopropylpropanoic acid hydrochloride

: 1402936-61-1
BAY 1101042

Guidance literature:: (+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid; With oxalyl dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.75h; Large scale;

(3S)-3-(3-amino-4-chlorophenyl)-3-cyclopropylpropanoic acid hydrochloride; With triethylsilyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1h; Large scale;

With hydrogenchloride; In ethyl acetate; Large scale;

Reference yield:

: 835629-56-6
(3R)-4,4,4-trifluoro-3-methylbutanoic acid

: 1402936-61-1
BAY 1101042

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 2 h / 80 °C

2.1: lithium hexamethyldisilazane / toluene / 0.17 h / -10 °C / Inert atmosphere

2.2: 16 h / 20 - 80 °C / Inert atmosphere; Cooling with acetone-dry ice

3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 50 °C

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C

4.2: 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With thionyl chloride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In 1,4-dioxane; dichloromethane; water; toluene;