tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate

Base Information

Chemical Name:tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate
CAS No.:1402937-56-7
Molecular Formula:C₂₇H₃₀Cl₂F₃NO₃
Molecular Weight:544.441
Hs Code.:

Synonyms:tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate

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Chemical Property of tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate

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Technology Process of tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate

There total 19 articles about tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1297550-14-1
(+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid

: tert-butyl (3S)-3-(3-amino-4-chlorophenyl)-3-cyclopropylpropanoate

: 1402937-56-7
tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate

Guidance literature:: (+)-(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid; With oxalyl dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

tert-butyl (3S)-3-(3-amino-4-chlorophenyl)-3-cyclopropylpropanoate; With pyridine; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 835629-56-6
(3R)-4,4,4-trifluoro-3-methylbutanoic acid

: 1402937-56-7
tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 2 h / 80 °C

2.1: lithium hexamethyldisilazane / toluene / 0.17 h / -10 °C / Inert atmosphere

2.2: 16 h / 20 - 80 °C / Inert atmosphere; Cooling with acetone-dry ice

3.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 50 °C

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C

4.2: 1 h / 20 °C

With thionyl chloride; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium hydroxide; lithium hexamethyldisilazane; In 1,4-dioxane; dichloromethane; water; toluene;

Reference yield:

: 1297549-70-2
(+)-ethyl (3R)-4,4,4-trifluoro-3-methylbutanoate

: 1402937-56-7
tert-butyl (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / toluene / 0.17 h / -10 °C / Inert atmosphere

1.2: 16 h / 20 - 80 °C / Inert atmosphere; Cooling with acetone-dry ice

2.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 50 °C

3.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 20 °C

3.2: 1 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium hydroxide; lithium hexamethyldisilazane; In 1,4-dioxane; dichloromethane; water; toluene;