(S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol

Base Information

Chemical Name:(S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol
CAS No.:128358-18-9
Molecular Formula:C₉H₁₅NO₄
Molecular Weight:201.222
Hs Code.:

Synonyms:(S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol

Chemical Property:

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Technology Process of (S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol

There total 1 articles about (S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 128358-17-8
<3aR-<1(S^*),3aα,6α,7aβ>>-1-<<4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolyl>carbonyl>hexahydro-8,8-dimethyl-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide

: 128358-18-9
(S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol

Guidance literature:: With L-Selectride; In tetrahydrofuran; at 25 ℃; for 0.5h;
DOI:10.1021/jo00302a023

Reference yield: 100.0%

: 128358-18-9
(S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol

: 98-59-9
p-toluenesulfonyl chloride

: 128358-19-0
(S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol 4-methylbenzenesulfonate ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 25 ℃; for 26h;
DOI:10.1021/jo00302a023

Reference yield:

: 128358-18-9
(S)-4,5-dihydro-3-<(2-methyl-1,3-dioxolan-2-yl)methyl>-5-isoxazolemethanol

: 95833-18-4
(+)-hepialone

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃N, DMAP / CH₂Cl₂ / 26 h / 25 °C

2: 1.) CuI/LiBr / 1.) ether, -5 deg C, 30 min, 2.) 18 h

3: 80 percent / boric acid, H₂ / Ra-Ni / methanol; H₂O / 1.5 h / 25 °C

4: 88 percent / aq. 3N HCl / diethyl ether / 20 h / 25 °C

With hydrogenchloride; dmap; copper(l) iodide; hydrogen; boric acid; triethylamine; lithium bromide; Ra-Ni; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo00302a023