(3-chloro-6-fluoro-1-benzothiophen-2-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone

Base Information

• Chemical Name: (3-chloro-6-fluoro-1-benzothiophen-2-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone
• CAS No.: 1254968-29-0
• Molecular Formula: C₁₉H₁₂ClFN₂O₂S
• Molecular Weight: 386.834

Synonyms:(3-chloro-6-fluoro-1-benzothiophen-2-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone

Chemical Property of (3-chloro-6-fluoro-1-benzothiophen-2-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone

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Technology Process of (3-chloro-6-fluoro-1-benzothiophen-2-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone

There total 1 articles about (3-chloro-6-fluoro-1-benzothiophen-2-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3-Chlor-6-fluor-benzo-thiophen-2-carbonsaeurechlorid (34576-83-5) + edaravone (89-25-8) → (3-chloro-6-fluoro-1-benzothiophen-2-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone (1254968-29-0)

Guidance literature:

With calcium hydroxide; In 1,4-dioxane; for 3h; Reflux;

DOI:10.1016/j.jfluchem.2010.07.007

Reference yield: 97.0%

(3-chloro-6-fluoro-1-benzothiophen-2-yl)(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methanone (1254968-29-0) → 7-fluoro-3-methyl-1-phenyl[1]benzothieno[20,30:5,6]pyrano[2,3-c]pyrazol-4(1H)-one (1254968-30-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 150 ℃;

DOI:10.1016/j.jfluchem.2010.07.007

upstream raw materials:

3-Chlor-6-fluor-benzo-thiophen-2-carbonsaeurechlorid

edaravone

Downstream raw materials:

7-fluoro-3-methyl-1-phenyl[1]benzothieno[20,30:5,6]pyrano[2,3-c]pyrazol-4(1H)-one

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