4-ethoxy-1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}butan-1-one

Base Information

Chemical Name:4-ethoxy-1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}butan-1-one
CAS No.:1353569-08-0
Molecular Formula:C₂₄H₃₀O₆
Molecular Weight:414.499
Hs Code.:

Synonyms:4-ethoxy-1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}butan-1-one

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Chemical Property of 4-ethoxy-1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}butan-1-one

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Technology Process of 4-ethoxy-1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}butan-1-one

There total 6 articles about 4-ethoxy-1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 64-17-5
ethanol

: 4-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}but-3-yn-1-ol

: 1353569-08-0
4-ethoxy-1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}butan-1-one

Guidance literature:: ethanol; 4-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}but-3-yn-1-ol; With toluene-4-sulfonic acid; at 170 ℃; for 0.5h; Microwave irradiation;

With water; In ethanol; at 20 ℃; regioselective reaction;
DOI:10.1002/cmdc.201100325

Reference yield:

: (3-iodo-4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone

: 1353569-08-0
4-ethoxy-1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}butan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 16 h / 60 °C

3.1: toluene-4-sulfonic acid / 0.5 h / 170 °C / Microwave irradiation

3.2: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; toluene-4-sulfonic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1.2: Wittig reaction / 2.1: Sonogashira-Linstrumelle coupling;
DOI:10.1002/cmdc.201100325

Reference yield:

: 5-[1-(3-iodo-4-methoxyphenyl)vinyl]-1,2,3-trimethoxybenzene

: 1353569-08-0
4-ethoxy-1-{2-methoxy-5-[1-(3,4,5-trimethoxyphenyl)vinyl]phenyl}butan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 16 h / 60 °C

2.1: toluene-4-sulfonic acid / 0.5 h / 170 °C / Microwave irradiation

2.2: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1.1: Sonogashira-Linstrumelle coupling;
DOI:10.1002/cmdc.201100325