4-chloro-2-(3-fluorophenyl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine

Base Information

Chemical Name:4-chloro-2-(3-fluorophenyl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine
CAS No.:1303588-06-8
Molecular Formula:C₁₂H₉ClFN₃O
Molecular Weight:265.674
Hs Code.:

Synonyms:4-chloro-2-(3-fluorophenyl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine

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Chemical Property of 4-chloro-2-(3-fluorophenyl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine

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Technology Process of 4-chloro-2-(3-fluorophenyl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine

There total 8 articles about 4-chloro-2-(3-fluorophenyl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1303588-05-7
4-chloro-2-(3-fluorophenyl)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one

: 1303588-06-8
4-chloro-2-(3-fluorophenyl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine

Guidance literature:: 4-chloro-2-(3-fluorophenyl)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one; With dimethylsulfide borane complex; In tetrahydrofuran; Reflux;

With methanol; In tetrahydrofuran; Reflux;

Reference yield:

: 403-54-3
m-Fluorobenzonitrile

: 1303588-06-8
4-chloro-2-(3-fluorophenyl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / Cooling with ice

2.1: ammonia / ethanol / -10 - -5 °C

3.1: sodium / methanol / 2 h / 0 °C / Reflux

4.1: trichlorophosphate / 22 h / Reflux

5.1: ammonium hydroxide / 21 h / 100 °C

6.1: boron tribromide / dichloromethane / 24 h / 20 °C

6.2: 20 °C

7.1: potassium carbonate / tetrahydrofuran / 26 h / 20 °C / Reflux

8.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux

8.2: Reflux

With hydrogenchloride; ammonium hydroxide; dimethylsulfide borane complex; ammonia; sodium; boron tribromide; potassium carbonate; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 75207-72-6
3-fluorobenzenecarboximidamide hydrochloride

: 1303588-06-8
4-chloro-2-(3-fluorophenyl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium / methanol / 2 h / 0 °C / Reflux

2.1: trichlorophosphate / 22 h / Reflux

3.1: ammonium hydroxide / 21 h / 100 °C

4.1: boron tribromide / dichloromethane / 24 h / 20 °C

4.2: 20 °C

5.1: potassium carbonate / tetrahydrofuran / 26 h / 20 °C / Reflux

6.1: dimethylsulfide borane complex / tetrahydrofuran / Reflux

6.2: Reflux

With ammonium hydroxide; dimethylsulfide borane complex; sodium; boron tribromide; potassium carbonate; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane;