4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester

Base Information

Chemical Name:4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester
CAS No.:1123157-92-5
Molecular Formula:C₄₀H₄₆O₈S
Molecular Weight:686.866
Hs Code.:

Synonyms:4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester

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Chemical Property of 4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester

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Technology Process of 4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester

There total 18 articles about 4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1123157-93-6
3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenol

: 1123157-63-0
4-[3-(6-bromohexyl)-2-(2-ethoxycarbonylethyl)phenoxy]butyric acid ethyl ester

: 1123157-92-5
4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetone; at 20 ℃; Inert atmosphere; Reflux;
DOI:10.1021/jm1001919

Reference yield: 53.5%

: 1123157-90-3
4-{2-(2-ethoxycarbonylethyl)-3-[6-(3-iodo-5-thiophen-3-ylphenoxy)hexyl]phenoxy}butyric acid ethyl ester

: 94839-07-3
3,4-(methylenedioxy)-benzeneboronic acid

: 1123157-92-5
4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; at 80 ℃; for 24.0833h;

Reference yield:

: C₃₆H₃₈O₅P⁽¹⁺⁾*Br^(1-)

: 1123157-92-5
4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / dimethyl sulfoxide / 0.25 h / -20 - 20 °C / Large scale

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 h / 40 °C / 28443.9 Torr / Autoclave; Large scale

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 45 °C / Large scale

3.2: 24 h / 65 - 67 °C / Large scale

With n-butyllithium; palladium 10% on activated carbon; hydrogen; potassium carbonate; In dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1.1: |Wittig Olefination;
DOI:10.1021/op300302s