S-t-butyl oxo-p-tolyl-thioacetate

Base Information

• Chemical Name: S-t-butyl oxo-p-tolyl-thioacetate
• CAS No.: 959161-61-6
• Molecular Formula: C₁₃H₁₆O₂S
• Molecular Weight: 236.335
• Mol file: 959161-61-6.mol

Synonyms:S-t-butyl oxo-p-tolyl-thioacetate

Chemical Property of S-t-butyl oxo-p-tolyl-thioacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-t-butyl oxo-p-tolyl-thioacetate

There total 5 articles about S-t-butyl oxo-p-tolyl-thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-t-butyl hydroxy-p-tolyl-thioacetate (959161-43-4) → (R)-S-t-butyl hydroxy-p-tolyl-thioacetate + (S)-S-t-butyl hydroxy-p-tolyl-thioacetate + S-t-butyl oxo-p-tolyl-thioacetate (959161-61-6)

Guidance literature:

With oxygen; chiral vanadium(V); In toluene; at 20 ℃; for 90h; Title compound not separated from byproducts.;

DOI:10.1021/jo070575f

Reference yield:

2-oxo-2-(p-tolyl)acetyl chloride (105457-91-8) + 2-methylpropan-2-thiol (75-66-1) → S-t-butyl oxo-p-tolyl-thioacetate (959161-61-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo070575f

Reference yield:

methyl 4-methylphenylglyoxylate (34966-53-5) → S-t-butyl oxo-p-tolyl-thioacetate (959161-61-6)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / H₂O; ethanol

2: oxalyl chloride / CH₂Cl₂ / 0.5 h / cooling

3: triethylamine / CH₂Cl₂ / 0 - 20 °C

With potassium hydroxide; oxalyl dichloride; triethylamine; In ethanol; dichloromethane; water;

DOI:10.1021/jo070575f

upstream raw materials:

2-oxo-2-(p-tolyl)acetyl chloride

2-methylpropan-2-thiol

S-t-butyl hydroxy-p-tolyl-thioacetate

methyl 4-methylphenylglyoxylate