C₁₉H₁₉NO₅S

Base Information

• Chemical Name: C₁₉H₁₉NO₅S
• CAS No.: 1372874-79-7
• Molecular Formula: C₁₉H₁₉NO₅S
• Molecular Weight: 373.43
• Mol file: 1372874-79-7.mol

Synonyms:C₁₉H₁₉NO₅S

Chemical Property of C₁₉H₁₉NO₅S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₉NO₅S

There total 5 articles about C₁₉H₁₉NO₅S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

7-[ethyl-(4-methanesulfonylphenyl)amino]-4-methylcoumarin (1346523-56-5) → C19H19NO5S (1372874-79-7)

Guidance literature:

7-[ethyl-(4-methanesulfonylphenyl)amino]-4-methylcoumarin; With selenium(IV) oxide; In para-xylene; for 24h; Reflux; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 3h;

DOI:10.1039/c2jm30357d

Reference yield:

N-(3-hydroxyphenyl)-4-methylbenzenesulfonamide (3743-29-1) → C19H19NO5S (1372874-79-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bismuth(III) chloride / 144 h / 75 °C

2.1: tetrabutylammomium bromide; potassium carbonate; sodium iodide / acetonitrile / 6 h / Reflux

3.1: selenium(IV) oxide / para-xylene / 24 h / Reflux; Inert atmosphere

3.2: 3 h / 20 °C

With selenium(IV) oxide; bismuth(III) chloride; tetrabutylammomium bromide; potassium carbonate; sodium iodide; In para-xylene; acetonitrile;

DOI:10.1039/c2jm30357d

Reference yield:

7-[N-(p-toluenesulfonyl)amino]-4-methylcoumarin (101973-09-5) → C19H19NO5S (1372874-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; potassium carbonate; sodium iodide / acetonitrile / 6 h / Reflux

2.1: selenium(IV) oxide / para-xylene / 24 h / Reflux; Inert atmosphere

2.2: 3 h / 20 °C

With selenium(IV) oxide; tetrabutylammomium bromide; potassium carbonate; sodium iodide; In para-xylene; acetonitrile;

DOI:10.1039/c2jm30357d

upstream raw materials:

7-[ethyl-(4-methanesulfonylphenyl)amino]-4-methylcoumarin

N-(3-hydroxyphenyl)-4-methylbenzenesulfonamide

7-[N-(p-toluenesulfonyl)amino]-4-methylcoumarin

p-toluenesulfonyl chloride

Refernces