(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)phenyl)(piperazin-1-yl)methanone

Base Information

Chemical Name:(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)phenyl)(piperazin-1-yl)methanone
CAS No.:1456928-84-9
Molecular Formula:C₂₄H₂₂N₄O₂
Molecular Weight:398.464
Hs Code.:

Synonyms:(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)phenyl)(piperazin-1-yl)methanone

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Chemical Property of (4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)phenyl)(piperazin-1-yl)methanone

Chemical Property:

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Technology Process of (4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)phenyl)(piperazin-1-yl)methanone

There total 7 articles about (4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)phenyl)(piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₂₉H₃₀N₄O₃

: 1456928-84-9
(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)phenyl)(piperazin-1-yl)methanone

Guidance literature:: With hydrogenchloride; In methanol; at 0 ℃; for 1h;
DOI:10.2174/1570180811310070010

Reference yield:

: 1456928-95-2
4-(5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl) phenol

: 1456928-84-9
(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)phenyl)(piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

2.1: lithium hydroxide; methanol / water / 4 h / 30 °C

3.1: HATU / N,N-dimethyl-formamide / 0.17 h / 25 °C / Inert atmosphere

3.2: 14 h

4.1: hydrogenchloride / methanol / 1 h / 0 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; HATU; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
DOI:10.2174/1570180811310070010

Reference yield:

: 1456928-96-3
ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate

: 1456928-84-9
(4-(3-(4-hydroxyphenyl)-1H-indazol-5-yl)phenyl)(piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; methanol / water / 4 h / 30 °C

2.1: HATU / N,N-dimethyl-formamide / 0.17 h / 25 °C / Inert atmosphere

2.2: 14 h

3.1: hydrogenchloride / methanol / 1 h / 0 °C

With hydrogenchloride; methanol; HATU; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.2174/1570180811310070010