ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate

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Chemical Name:ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate
CAS No.:1456928-96-3
Molecular Formula:C₂₇H₂₆N₂O₄
Molecular Weight:442.514
Hs Code.:

Synonyms:ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate

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Chemical Property of ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate

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Technology Process of ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate

There total 4 articles about ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1456928-95-2
4-(5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl) phenol

: 4334-88-7
p-ethoxycarbonylphenylboronic acid

: 1456928-96-3
ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Inert atmosphere;
DOI:10.2174/1570180811310070010

Reference yield:

: 53857-57-1
5-bromo-1H-indazole

: 1456928-96-3
ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere

2: toluene-4-sulfonic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

4: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iodine; sodium carbonate; toluene-4-sulfonic acid; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide; 3: |Suzuki Coupling / 4: |Suzuki Coupling;
DOI:10.2174/1570180811310070010

Reference yield:

: 459133-66-5
5-bromo-3-iodo-1H-indazole

: 1456928-96-3
ethyl 4-(3-(4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

3: water; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.2174/1570180811310070010