3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyl-4-triazoleuridine

Base Information

• Chemical Name: 3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyl-4-triazoleuridine
• CAS No.: 195253-09-9
• Molecular Formula: C₃₈H₄₁N₅O₉
• Molecular Weight: 711.772
• Mol file: 195253-09-9.mol

Synonyms:3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyl-4-triazoleuridine

Chemical Property of 3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyl-4-triazoleuridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyl-4-triazoleuridine

There total 1 articles about 3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyl-4-triazoleuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,4-Triazole (288-88-0) + 3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyluridine (182495-98-3) → 3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyl-4-triazoleuridine (195253-09-9)

Guidance literature:

1,2,4-Triazole; With triethylamine; In acetonitrile; at -5 ℃; for 0.5h;

With trichlorophosphate; In acetonitrile; at 0 - 10 ℃; for 2.5h;

3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyluridine; In acetonitrile;

Reference yield: 95.0%

3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyl-4-triazoleuridine (195253-09-9) → 2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methylcytidine (182496-00-0)

Guidance literature:

3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyl-4-triazoleuridine; With ammonia; In 1,4-dioxane; water; at 20 ℃; for 2h;

With ammonia; In methanol; at 100 ℃; for 2h;

upstream raw materials:

1,2,4-Triazole

3'-O-acetyl-2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methyluridine

Downstream raw materials:

2'-O-methoxyethyl-5'-O-dimethoxytrityl-5-methylcytidine