11'-(4-methoxyphenylamino)vinorelbine trifluoroacetate

Base Information

Chemical Name:11'-(4-methoxyphenylamino)vinorelbine trifluoroacetate
CAS No.:854607-21-9
Molecular Formula:C₂HF₃O₂*C₅₂H₆₁N₅O₉
Molecular Weight:1014.11
Hs Code.:

Synonyms:11'-(4-methoxyphenylamino)vinorelbine trifluoroacetate

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Chemical Property of 11'-(4-methoxyphenylamino)vinorelbine trifluoroacetate

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Technology Process of 11'-(4-methoxyphenylamino)vinorelbine trifluoroacetate

There total 4 articles about 11'-(4-methoxyphenylamino)vinorelbine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 854607-32-2
11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine

: 76-05-1
trifluoroacetic acid

: 854607-21-9
11'-(4-methoxyphenylamino)vinorelbine trifluoroacetate

Guidance literature:: 11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1.5h;

trifluoroacetic acid;

Reference yield:

: 854606-59-0
11'-iodovinorelbine

: 854607-21-9
11'-(4-methoxyphenylamino)vinorelbine trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

2: sodium t-butanolate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 80 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 125317-39-7
vinorelibine bitartrate

: 854607-21-9
11'-(4-methoxyphenylamino)vinorelbine trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodo-succinimide; trifluoroacetic acid / 1.25 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

3: sodium t-butanolate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 80 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h

With N-iodo-succinimide; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene;