11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine

Base Information

Chemical Name:11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine
CAS No.:854607-32-2
Molecular Formula:C₅₈H₇₅N₅O₉Si
Molecular Weight:1014.35
Hs Code.:

Synonyms:11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine

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Chemical Property of 11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine

Chemical Property:

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Technology Process of 11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine

There total 4 articles about 11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 854607-28-6
11'-iodo-3-(tert-butyldimethylsilanyloxy)vinorelbine

: 104-94-9
4-methoxy-aniline

: 854607-32-2
11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine

Guidance literature:: With sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 80 ℃; for 4h;

Reference yield:

: 854606-59-0
11'-iodovinorelbine

: 854607-32-2
11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

2: sodium t-butanolate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 80 °C

With N-ethyl-N,N-diisopropylamine; sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; toluene;

Reference yield:

: 125317-39-7
vinorelibine bitartrate

: 854607-32-2
11'-(4-methoxyphenylamino)-3-(tert-butyldimethylsilanyloxy)vinorelbine

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide; trifluoroacetic acid / 1.25 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h

3: sodium t-butanolate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 4 h / 80 °C

With N-iodo-succinimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In dichloromethane; toluene;