[4-(5-bromo-6-methoxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-acetic acid methyl ester

Base Information

Chemical Name:[4-(5-bromo-6-methoxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-acetic acid methyl ester
CAS No.:868730-19-2
Molecular Formula:C₂₀H₁₅BrCl₂O₃
Molecular Weight:454.147
Hs Code.:

Synonyms:[4-(5-bromo-6-methoxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-acetic acid methyl ester

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Chemical Property of [4-(5-bromo-6-methoxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-acetic acid methyl ester

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Technology Process of [4-(5-bromo-6-methoxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-acetic acid methyl ester

There total 6 articles about [4-(5-bromo-6-methoxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 868730-15-8
[3,5-dichloro-4-(6-methoxy-naphthalen-1-yl)-phenyl]-acetic acid methyl ester

: 868730-19-2
[4-(5-bromo-6-methoxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-acetic acid methyl ester

Guidance literature:: With hydrogen bromide; acetic acid; In dimethyl sulfoxide; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2005.06.093

Reference yield:

: 22604-07-5
6-methoxy-1-naphthol

: 868730-19-2
[4-(5-bromo-6-methoxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / Et₃N / CH₂Cl₂ / -40 - -10 °C

2: 58 percent / potassium acetate / PdCl₂(dppf) / 4 h / 80 °C

3: 9 percent / K₂CO₃; Pd(PPh₃)4 / toluene; acetone / 4 h / 80 °C

4: 97 percent / aq. HBr; acetic acid / dimethylsulfoxide / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; potassium acetate; potassium carbonate; acetic acid; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; dimethyl sulfoxide; acetone; toluene; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.06.093

Reference yield:

: 350584-53-1
6-(methyloxy)-1-naphthalenyl trifluoromethanesulfonate

: 868730-19-2
[4-(5-bromo-6-methoxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / potassium acetate / PdCl₂(dppf) / 4 h / 80 °C

2: 9 percent / K₂CO₃; Pd(PPh₃)4 / toluene; acetone / 4 h / 80 °C

3: 97 percent / aq. HBr; acetic acid / dimethylsulfoxide / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; potassium acetate; potassium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; acetone; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.06.093