diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate

Base Information

Chemical Name:diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate
CAS No.:1354716-14-5
Molecular Formula:C₂₇H₃₅NO₈
Molecular Weight:501.577
Hs Code.:

Synonyms:diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate

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Technology Process of diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate

There total 2 articles about diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₄₃NO₈Si

: 1354716-14-5
diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate

Guidance literature:: With trifluoroacetic acid; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jo202398q

Reference yield:

: 1354716-12-3
C₁₄H₂₀O₅

: 131685-53-5,101711-78-8
(S)-4-benzyl-3-propionyl-2-oxazolidinone

: 1354716-14-5
diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexafluoroantimonate; triethylamine; magnesium chloride / ethyl acetate / 24 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

With sodium hexafluoroantimonate; triethylamine; trifluoroacetic acid; magnesium chloride; In methanol; ethyl acetate; 1: Aldol condensation;
DOI:10.1021/jo202398q

Reference yield: 83.0%

: 1354716-14-5
diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate

: 1354716-10-1
(S)-4-benzyl-3-((2R,3R)-3-hydroxy-2-methylpent-4-enoyl)-oxazolidin-2-one

: 21622-00-4
Cyclopent-3-ene-1,1-dicarboxylic acid diethyl ester

Guidance literature:: With Hoveyda-Blechert second generation catalyst; In ethene; toluene; at 60 ℃; for 12h; under 760.051 Torr; Inert atmosphere;
DOI:10.1021/jo202398q