(6R,7R,E)-8-((S)-4-benzyl-2-oxooxazolidin-3-yl)-6-hydroxy-7-methyl-3-methylene-8-oxooct-4-en-2-yl benzoate

Base Information

Chemical Name:(6R,7R,E)-8-((S)-4-benzyl-2-oxooxazolidin-3-yl)-6-hydroxy-7-methyl-3-methylene-8-oxooct-4-en-2-yl benzoate
CAS No.:1354716-16-7
Molecular Formula:C₂₇H₂₉NO₆
Molecular Weight:463.53
Hs Code.:

Synonyms:(6R,7R,E)-8-((S)-4-benzyl-2-oxooxazolidin-3-yl)-6-hydroxy-7-methyl-3-methylene-8-oxooct-4-en-2-yl benzoate

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Chemical Property of (6R,7R,E)-8-((S)-4-benzyl-2-oxooxazolidin-3-yl)-6-hydroxy-7-methyl-3-methylene-8-oxooct-4-en-2-yl benzoate

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Technology Process of (6R,7R,E)-8-((S)-4-benzyl-2-oxooxazolidin-3-yl)-6-hydroxy-7-methyl-3-methylene-8-oxooct-4-en-2-yl benzoate

There total 3 articles about (6R,7R,E)-8-((S)-4-benzyl-2-oxooxazolidin-3-yl)-6-hydroxy-7-methyl-3-methylene-8-oxooct-4-en-2-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1354716-10-1
(S)-4-benzyl-3-((2R,3R)-3-hydroxy-2-methylpent-4-enoyl)-oxazolidin-2-one

: 29333-27-5,7342-11-2
but-3-yn-2-yl benzoate

: 1354716-16-7
(6R,7R,E)-8-((S)-4-benzyl-2-oxooxazolidin-3-yl)-6-hydroxy-7-methyl-3-methylene-8-oxooct-4-en-2-yl benzoate

Guidance literature:: With Hoveyda-Blechert second generation catalyst; In 1,2-dichloro-ethane; at 45 ℃; for 14h; Inert atmosphere;
DOI:10.1021/jo202398q

Reference yield: 46.0%

: 1354716-14-5
diethyl 2-allyl-2-((4R,5R,E)-6-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-hydroxy-5-methyl-6-oxohex-2-enyl)malonate

: 29333-27-5,7342-11-2
but-3-yn-2-yl benzoate

: 1354716-10-1
(S)-4-benzyl-3-((2R,3R)-3-hydroxy-2-methylpent-4-enoyl)-oxazolidin-2-one

: 1354716-16-7
(6R,7R,E)-8-((S)-4-benzyl-2-oxooxazolidin-3-yl)-6-hydroxy-7-methyl-3-methylene-8-oxooct-4-en-2-yl benzoate

Guidance literature:: With Hoveyda-Blechert second generation catalyst; In toluene; at 60 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo202398q

Reference yield:

: 3-((4E)(2R,3R)-3-hydroxy-2-methyl5-phenylpent-4-enoyl)(4S)-4-benzyl-1,3-oxazolidin-2-one

: 1354716-16-7
(6R,7R,E)-8-((S)-4-benzyl-2-oxooxazolidin-3-yl)-6-hydroxy-7-methyl-3-methylene-8-oxooct-4-en-2-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: Hoveyda-Blechert second generation catalyst / 1,2-dichloro-ethane / 12 h / 3102.97 Torr / Inert atmosphere

2: Hoveyda-Blechert second generation catalyst / 1,2-dichloro-ethane / 14 h / 45 °C / Inert atmosphere

With Hoveyda-Blechert second generation catalyst; In 1,2-dichloro-ethane;
DOI:10.1021/jo202398q