2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carboxylic acid amide

Base Information

Chemical Name:2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carboxylic acid amide
CAS No.:1341125-89-0
Molecular Formula:C₁₈H₂₁NO₄
Molecular Weight:315.369
Hs Code.:

Synonyms:2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carboxylic acid amide

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Chemical Property of 2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carboxylic acid amide

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Technology Process of 2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carboxylic acid amide

There total 8 articles about 2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1341125-88-9
2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carbonitrile

: 1341125-89-0
2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carboxylic acid amide

Guidance literature:: With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 2h;
DOI:10.1055/s-0030-1260115

Reference yield:

: 1341125-81-2
1-[3-hydroxy-3-(4-isopropoxyphenyl)prop-1-ynyl]cyclopentanol

: 1341125-89-0
2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: manganese(IV) oxide / dichloromethane / 1.5 h / 20 °C

2.1: water; diethylamine / ethanol / 0.5 h / 20 °C

3.1: bromine / dichloromethane / 0.33 h / 0 °C

3.2: 3 h / 0 - 20 °C

4.1: nickel dibromide / 1-methyl-pyrrolidin-2-one / 200 °C / Sealed vessel; Microwave irradiation

5.1: water; sodium hydroxide / 1,4-dioxane / 2 h / 20 °C

With manganese(IV) oxide; water; bromine; diethylamine; sodium hydroxide; nickel dibromide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; 4.1: Rosenmund von Braun reaction;
DOI:10.1055/s-0030-1260115

Reference yield:

: 1341125-86-7
3-bromo-2-(4-isopropoxyphenyl)-1-oxaspiro[4.4]non-2-en-4-one

: 1341125-89-0
2-(4-isopropoxyphenyl)-4-oxo-1-oxaspiro[4.4]non-2-ene-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: nickel dibromide / 1-methyl-pyrrolidin-2-one / 200 °C / Sealed vessel; Microwave irradiation

2: water; sodium hydroxide / 1,4-dioxane / 2 h / 20 °C

With water; sodium hydroxide; nickel dibromide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1: Rosenmund von Braun reaction;
DOI:10.1055/s-0030-1260115