2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester

Base Information

Chemical Name:2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester
CAS No.:214842-50-9
Molecular Formula:C₂₁H₂₄N₄O₅S₃
Molecular Weight:508.643
Hs Code.:

Synonyms:2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester

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Chemical Property of 2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester

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Technology Process of 2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester

There total 7 articles about 2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 214842-37-2
2-[2-(4-Cyano-benzenesulfonylamino)-acetylamino]-3-(4-cyano-phenyl)-propionic acid ethyl ester

: 214842-50-9
2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester

Guidance literature:: With pyridine; hydrogen sulfide; triethylamine; for 120h;
DOI:10.1021/jm980227t

Reference yield:

: 17201-43-3
4-cyanobenzyl bromide

: 214842-50-9
2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / tetrabutylammonium bromide, K₂CO₃ / acetonitrile / 48 h

2: 80 percent / 1 M HCl / diethyl ether / 22 h

3: 99 percent / Et₃N / dimethylformamide / 72 h

4: 93 percent / H₂S, Et₃N, pyridine / 120 h

With pyridine; hydrogenchloride; hydrogen sulfide; tetrabutylammomium bromide; potassium carbonate; triethylamine; In diethyl ether; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980227t

Reference yield:

: 49584-26-1
p-cyanobenzenesulfonyl chloride

: 214842-50-9
2-[2-(4-Thiocarbamoyl-benzenesulfonylamino)-acetylamino]-3-(4-thiocarbamoyl-phenyl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / 1 M NaOH / diethyl ether / 20 h / Ambient temperature

2: 91 percent / DCCl / dioxane / 4 °C

3: 99 percent / Et₃N / dimethylformamide / 72 h

4: 93 percent / H₂S, Et₃N, pyridine / 120 h

With pyridine; sodium hydroxide; hydrogen sulfide; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm980227t