(4R,5S)-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-4-methoxycarbonyl-1,3-dioxolane

Base Information

• Chemical Name: (4R,5S)-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-4-methoxycarbonyl-1,3-dioxolane
• CAS No.: 1247028-43-8
• Molecular Formula: C₂₀H₃₀O₆
• Molecular Weight: 366.455
• Mol file: 1247028-43-8.mol

Synonyms:(4R,5S)-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-4-methoxycarbonyl-1,3-dioxolane

Chemical Property of (4R,5S)-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-4-methoxycarbonyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (4R,5S)-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-4-methoxycarbonyl-1,3-dioxolane

There total 1 articles about (4R,5S)-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-4-methoxycarbonyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2R,3S)-methyl 2,3-dihydroxy-8-(4-methoxybenzyloxy)octanoate + 2,2-dimethoxy-propane (77-76-9) → (4R,5S)-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-4-methoxycarbonyl-1,3-dioxolane (1247028-43-8)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/jo101416x

Reference yield: 99.0%

(4R,5S)-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-4-methoxycarbonyl-1,3-dioxolane (1247028-43-8) → (4S,5S)-4-hydroxymethyl-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-1,3-dioxolane (1247028-45-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 19h; Inert atmosphere;

DOI:10.1021/jo101416x

upstream raw materials:

2,2-dimethoxy-propane

Downstream raw materials:

(4S,5S)-4-hydroxymethyl-5-[5-(4-methoxybenzyloxy)pentyl]-2,2-dimethyl-1,3-dioxolane