ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Base Information

• Chemical Name: ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate
• CAS No.: 1312776-48-9
• Molecular Formula: C₂₉H₃₂N₃O₆P*H₃N
• Molecular Weight: 566.594
• Mol file: 1312776-48-9.mol

Synonyms:ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Chemical Property of ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate

There total 1 articles about ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate (1312776-47-8) → ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate (1312776-48-9)

Guidance literature:

With ammonium hydroxide; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.04.126

Reference yield:

ammonium ethyl ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate (1312776-48-9) + N-(tert-butoxycarbonyl)-L-alanyl-L-serine methyl ester (71017-97-5) → C41H52N5O11P

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 40 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.04.126

upstream raw materials:

lithium ethyl ({[(2S)-1-[4-(benzoylamino)-2-oxopyrimidin-1(2H)-yl]-3-(trityloxy)propan-2-yl]oxy}methyl)phosphonate