5-benzyl-2-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one

Base Information

Chemical Name:5-benzyl-2-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one
CAS No.:1621508-53-9
Molecular Formula:C₂₅H₃₈N₄O₃Si
Molecular Weight:470.687
Hs Code.:

Synonyms:5-benzyl-2-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one

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Chemical Property of 5-benzyl-2-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one

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Technology Process of 5-benzyl-2-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one

There total 16 articles about 5-benzyl-2-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1621508-52-8
1-benzyl-N-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-2-(hydroxymethyl)-5-methylpyrrolidine-2-carboxamide

: 1621508-53-9
5-benzyl-2-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 1621508-43-7
ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate

: 1621508-53-9
5-benzyl-2-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; palladium 10% on activated carbon / water; methanol / 16 h / 20 °C

2: potassium carbonate / acetonitrile / 16 h / 20 °C

3: sodium hydroxide; water / ethanol / 2 h / 100 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1621508-45-9
ethyl 1-benzyl-2-(hydroxymethyl)-5-methylpyrrolidine-2-carboxylate

: 1621508-53-9
5-benzyl-2-((1S,2R)-2-((tert-butoxydimethylsilyl)oxy)-1-(1,3,4-oxadiazol-2-yl)propyl)-6-methyl-2,5-diazaspiro[3.4]octan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol / 2 h / 100 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C

With di-isopropyl azodicarboxylate; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;