ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate

Base Information

Chemical Name:ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate
CAS No.:1621508-43-7
Molecular Formula:C₂HF₃O₂*C₁₆H₂₃NO₃
Molecular Weight:391.387
Hs Code.:

Synonyms:ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate

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Chemical Property of ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate

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Technology Process of ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate

There total 6 articles about ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621435-42-4
1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-1,2-dicarboxylate

: 76-05-1
trifluoroacetic acid

: 1621508-43-7
ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 251924-83-1
1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate

: 1621508-43-7
ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran; diethyl ether / 2 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.1: hydrogen; palladium 10% on activated carbon / water; ethanol / 16 h

4.1: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

5.2: 2 h / -30 °C

6.1: dichloromethane / 4 h / 0 - 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;

Reference yield:

: (S)-ethyl 2-((tert-butoxycarbonyl)amino)-5-oxohexanoate

: 1621508-43-7
ethyl 2-((benzyloxy)methyl)-5-methylpyrrolidine-2-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

2.1: hydrogen; palladium 10% on activated carbon / water; ethanol / 16 h

3.1: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

4.2: 2 h / -30 °C

5.1: dichloromethane / 4 h / 0 - 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water;