(S)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

Base Information

Chemical Name:(S)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide
CAS No.:1437318-12-1
Molecular Formula:C₂₁H₂₅N₃O₅
Molecular Weight:399.447
Hs Code.:

Synonyms:(S)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

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Chemical Property of (S)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

Chemical Property:

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Technology Process of (S)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

There total 4 articles about (S)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10312-83-1
methoxyacetaldehyde

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 64-19-7,77671-22-8
acetic acid

: 132873-57-5,92203-66-2
(S)-(-)-α-methyl-4-nitrobenzylamine hydrochloride

: 1437318-11-0
(R)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

: 1437318-12-1
(S)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

Guidance literature:: (S)-(-)-α-methyl-4-nitrobenzylamine hydrochloride; With triethylamine; In methanol; at 20 ℃; for 0.166667h;

methoxyacetaldehyde; Benzyl isocyanide; acetic acid; In methanol; water; at 20 ℃; for 18h; Overall yield = 100%; Overall yield = 2.5g;

Reference yield:

: 100-46-9
benzylamine

: 1437318-11-0
(R)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

: 1437318-12-1
(S)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: Reflux

2: methanesulfonyl chloride; pyridine / toluene / 1 h / 35 - 40 °C

With pyridine; methanesulfonyl chloride; In toluene; 3: |Ugi Condensation;
DOI:10.1021/acs.oprd.5b00228

Reference yield:

: 103-81-1
Benzeneacetamide

: 1437318-11-0
(R)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

: 1437318-12-1
(S)-2-{acetyl-[(S)-1-(4-nitro-phenyl)-ethyl]-amino}-N-benzyl-3-methoxy-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonyl chloride; pyridine / toluene / 1 h / 35 - 40 °C

With pyridine; methanesulfonyl chloride; In toluene; 2: |Ugi Condensation;
DOI:10.1021/acs.oprd.5b00228