benzyl 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>2-<(N-trifluoroacetylprolyloxy)-d-methyl>pyrrole-5-carboxylate

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Chemical Name:benzyl 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>2-<(N-trifluoroacetylprolyloxy)-d-methyl>pyrrole-5-carboxylate
CAS No.:143085-37-4
Molecular Formula:C₂₇H₂₉F₃N₂O₉
Molecular Weight:583.523
Hs Code.:

Synonyms:benzyl 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>2-<(N-trifluoroacetylprolyloxy)-d-methyl>pyrrole-5-carboxylate

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Chemical Property of benzyl 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>2-<(N-trifluoroacetylprolyloxy)-d-methyl>pyrrole-5-carboxylate

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Technology Process of benzyl 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>2-<(N-trifluoroacetylprolyloxy)-d-methyl>pyrrole-5-carboxylate

There total 6 articles about benzyl 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>2-<(N-trifluoroacetylprolyloxy)-d-methyl>pyrrole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 36724-68-2
(S)-N-trifluoroacetylproline acid chloride

: 143085-35-2
benzyl 2-hydroxy-d-methyl-4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>pyrrole-5-carboxylate

: 143085-37-4
benzyl 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>2-<(N-trifluoroacetylprolyloxy)-d-methyl>pyrrole-5-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; for 4h; Heating;
DOI:10.1016/S0040-4020(01)81567-2

Reference yield:

: 72423-67-7
benzyl 2-iodo-3<(methoxycarbonyl)methyl>-4-<β-(methoxycarbonyl)ethyl>-5-pyrrolecarboxylate

: 143085-37-4
benzyl 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>2-<(N-trifluoroacetylprolyloxy)-d-methyl>pyrrole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / H₂, Et₃N / PtO₂ / methanol / 3 h / Ambient temperature

2: 1.) pocL₃ / 1.) CH₂Cl₂, r. t., 30 min, 2.) overnight

3: 1.) R-alpine borane, 2.) 2-aminoethanol / 1.) THF, r. t., overnight

4: 71 percent / Et₃N / CH₂Cl₂ / 4 h / Heating

With B-isopinocampheyl-9-borabicyclo[3.3.1]nonane; hydrogen; ethanolamine; triethylamine; trichlorophosphate; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)81567-2

Reference yield:

: 72423-57-5
5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3methoxycarbonylmethylpyrrole-2-carboxylic acid

: 143085-37-4
benzyl 4-<2-(methoxycarbonyl)ethyl>-3-<(methoxycarbonyl)methyl>2-<(N-trifluoroacetylprolyloxy)-d-methyl>pyrrole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / 1.) NaHCO₃, 2.) I₂, KI / 1.) H₂O, CH₂Cl₂, reflux, 2.) H₂O, reflux, 0.5 h

2: 72 percent / H₂, Et₃N / PtO₂ / methanol / 3 h / Ambient temperature

3: 1.) pocL₃ / 1.) CH₂Cl₂, r. t., 30 min, 2.) overnight

4: 1.) R-alpine borane, 2.) 2-aminoethanol / 1.) THF, r. t., overnight

5: 71 percent / Et₃N / CH₂Cl₂ / 4 h / Heating

With B-isopinocampheyl-9-borabicyclo[3.3.1]nonane; hydrogen; iodine; sodium hydrogencarbonate; ethanolamine; triethylamine; potassium iodide; trichlorophosphate; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)81567-2