72423-57-5Relevant academic research and scientific papers
New method for the synthesis of pyrromethanes
Okada, Kunisuke,Saburi, Kiyoshi,Nomura, Keishi,Tanino, Hideo
, p. 2127 - 2131 (2007/10/03)
Coupling reaction of 2-mercaptobenzothiazolylmethylpyrrole with α-free pyrrole in the presence of silver(I) triflate proceeds smoothly at room temperature to give a pyrromethane in excellent yield. The azafulvenium ion, an active form that reacts with α-f
2-Mercaptobenzothiazolylmethylpyrrole as a new means for the synthesis of pyrromethanes under neutral conditions
Okada, Kunisuke,Saburi, Kiyoshi,Nomura, Keishi,Tanino, Hideo
, p. 2365 - 2366 (2007/10/03)
The coupling reaction of 2-mercaptobenzothiazolylmethylpyrrole 4b with α-free pyrrole 2b in the presence of silver (I) triflate proceeds smoothly at room temperature to give pyrromethane 1b in excellent yield. 4b reacts rapidly with pyrromethane 1b under
On the Mechanism of Porphobilinogen Deaminase. Design, Synthesis, and Enzymatic Reactions of Novel Porphobilinogen Analogs.
Pichon, Clotilde,Clemens, Karen R.,Jacobson, Alan R.,Scott, A. Ian
, p. 4687 - 4712 (2007/10/02)
Three new derivatives of porphobilinogen (PBG; 1) were designed and synthesized to study the mechanism of ammonia loss during the tetramerization of PBG, catalyzed by the PBG deaminase.Two of these compounds are substituted at the C-11 carbon with CH3 or
Synthetic and Biosynthetic Studies of Porphyrins. Part 9. Synthesis of Isocoproporphyrin, Dehydroisocoproporphyrin, and De-ethylisocopropophyrin
Jackson, Anthony H.,Lash, Timothy D.,Ryder, David J.
, p. 287 - 298 (2007/10/02)
The title compounds, which were extracted by patients suffering from porphyria cutanea tarda or rats poisoned with hexachlorobenzene have been synthesized by the b-oxobilane route.Isocoproporphyrin tetramethyl ester (7a) were prepared from pyrromethanes c
Biosynthesis of Porphyrins and Related Macrocycles. Part 17. Chemical and Enzymic Transformation of Isomeric Aminomethylbilanes into Uroporphyrinogens: Proof that Unrearranged Bilane is the Preferred Enzymic Substrate and Detection of a Transient Intermed
Battersby, Alan R.,Fookes, Christopher J. R.,Gustafson-Potter, Kerstin E.,McDonald, Edward,Matcham, George W. J.
, p. 2413 - 2426 (2007/10/02)
Six isomeric aminomethylbilanes have been built by unambiguous synthesis.One bilane has the unrearranged structure corresponding to straightforward head-to-tail assembly of four units of porphobilinogen; the other five bilanes have one or more of the pyrr
SYNTHESIS OF UROPORPHYRIN-III, AND RELATED HEPTA- AND PENTA-CARBOXYLIC PORPHYRINS BY MODIFICATIONS OF THE MACDONALD METHOD
Chakrabarty, M.,Ali, S. A.,Philip, G.,Jackson, A. H.
, p. 1199 - 1204 (2007/10/02)
A modification of the MacDonald route has been developed in which all four pyrrole units of uroporphyrin-III have been derived from the same conveniently prepared starting pyrrole.Related hepta- and penta-carboxylic porphyrins have also been synthesised by condensation of appropriate α-formyl pyrromethane-α'-carboxylic acids; in each case other porphyrins with different numbers of acidic side-chains were also produced but the desired products were easily separated (as their methyl esters) by h.p.l.c.
Synthesis of Bilanes of Biosynthetic Interest
Diaz, Luis,Valasinas, Aldonia,Frydman, Benjamin
, p. 864 - 867 (2007/10/02)
A series of bilanes of biosynthetic interest and formally derived from porphobilinogen were prepared by reduction of the corresponding b-bilenes.The latter were prepared by condensation of a -5-formyldipyrryl>methane with dipy
