(2R)-2-Methyl-2-[3-(benzyloxy)propyl]cyclohexanone

Base Information

Chemical Name:(2R)-2-Methyl-2-[3-(benzyloxy)propyl]cyclohexanone
CAS No.:201209-93-0
Molecular Formula:C₁₇H₂₄O₂
Molecular Weight:260.376
Hs Code.:
DSSTox Substance ID:DTXSID501208466
Nikkaji Number:J983.874K

Synonyms:DTXSID501208466;201209-93-0;(2R)-2-Methyl-2-[3-(benzyloxy)propyl]cyclohexanone;(2R)-2-Methyl-2-[3-(phenylmethoxy)propyl]cyclohexanone

Suppliers and Price of (2R)-2-Methyl-2-[3-(benzyloxy)propyl]cyclohexanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-2-Methyl-2-[3-(benzyloxy)propyl]cyclohexanone

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:260.177630004
Heavy Atom Count:19
Complexity:281

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CCCCC1=O)CCCOCC2=CC=CC=C2
Isomeric SMILES:C[C@@]1(CCCCC1=O)CCCOCC2=CC=CC=C2

Technology Process of (2R)-2-Methyl-2-[3-(benzyloxy)propyl]cyclohexanone

There total 16 articles about (2R)-2-Methyl-2-[3-(benzyloxy)propyl]cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: C₁₉H₂₈O₃

: 201209-93-0
(+)-2-(3-benzyloxypropyl)-2-methylcyclohexanone

Guidance literature:: With toluene-4-sulfonic acid; In water; acetone; at 50 ℃; for 2h; Schlenk technique; Inert atmosphere;
DOI:10.1002/anie.202105384

Reference yield: 100.0%

: 201210-08-4
(R)-2-(3-Benzyloxy-propyl)-2-methyl-cyclohexanol

: 201209-93-0
(+)-2-(3-benzyloxypropyl)-2-methylcyclohexanone

Guidance literature:: With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; In dichloromethane;
DOI:10.1021/jo972208h

Reference yield:

: 111-16-0
heptanedioic acid

: 201209-93-0
(+)-2-(3-benzyloxypropyl)-2-methylcyclohexanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / toluene / 18 h / 120 °C / Dean-Stark; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 17 h / 40 °C / Schlenk technique; Inert atmosphere; Cooling

2.2: 23 h / 40 °C / Schlenk technique; Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (R)-4-(tert-butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole / tetrahydrofuran / 21 h / 30 °C / Schlenk technique; Inert atmosphere

3.2: 60 °C / Schlenk technique; Inert atmosphere

4.1: pyridinium p-toluenesulfonate / benzene / 3 h / 105 °C / Dean-Stark; Inert atmosphere

5.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 2.5 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

5.2: 20 h / 0 - 20 °C / Schlenk technique; Inert atmosphere

6.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Schlenk technique; Inert atmosphere

6.2: 0 - 20 °C / Schlenk technique; Inert atmosphere

7.1: toluene-4-sulfonic acid / water; acetone / 2 h / 50 °C / Schlenk technique; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 9-borabicyclo[3.3.1]nonane dimer; (R)-4-(tert-butyl)-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; water; acetone; toluene; mineral oil; benzene;
DOI:10.1002/anie.202105384