Technology Process of (S)-3-acetyl-1-benzyl-4-isopropylimidazolidin-2-one
There total 6 articles about (S)-3-acetyl-1-benzyl-4-isopropylimidazolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-1-benzyl-4-isopropyl-imidazolidin-2-one;
With
sodium hydride;
In
tetrahydrofuran; paraffin oil;
at 0 ℃;
for 1h;
Inert atmosphere;
acetyl chloride;
In
tetrahydrofuran; paraffin oil;
Inert atmosphere;
DOI:10.1021/ol300949s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride; water / methanol / 4 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / Inert atmosphere; Reflux
4.1: potassium carbonate / water; toluene / 0 - 20 °C
5.1: sodium hydride / tetrahydrofuran; paraffin oil / 1 h / 0 °C / Inert atmosphere
5.2: Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; water; chloroformic acid ethyl ester; sodium hydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; paraffin oil;
DOI:10.1021/ol300949s
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / tetrahydrofuran; water / 12 h
2.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride; water / methanol / 4 h / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / Inert atmosphere; Reflux
5.1: potassium carbonate / water; toluene / 0 - 20 °C
6.1: sodium hydride / tetrahydrofuran; paraffin oil / 1 h / 0 °C / Inert atmosphere
6.2: Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; water; chloroformic acid ethyl ester; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene; paraffin oil;
DOI:10.1021/ol300949s
